| sdhC | succinate dehydrogenase, cytochrome b556 subunit | Mutants expressing a dominant negative form of sdhC in the nervous system have a 22% reduced mean lifespan and signs of oxidative stress induction [17854771]. | Fruit fly |
| SNF1 | Sucrose NonFermenting 1 | Forced overexpression (high-copy 2 micro expression) of SNF1 shortens replicative lifespan to 75% of wild-type and is accompanied by signs of premature ageing, including progressive sterility, enlargement and fragmentation of the nucleus, redistribution of Sir3 to the nucleus, and more rapid accumulation of extrachromosomal rDNA circles [10921902]. SNF1 overexpression also reduced chronological lifespan [19164565]. Deletion of SNF1 increases replicative lifespan by 50% in the alpha strain [19030232], but decreases chronological lifespan [21076178]. | Budding yeast |
| SNF4 | Sucrose NonFermenting 4 | Deleting SNF4 extends replicative lifespan by 10-20% in S288C strain [10921902].
| Budding yeast |
| tdp-1 | TAR DNA-binding Protein homolog 1 | tdp-1(ok803) mutation increases mean and maximum lifespan at 20 degree Celsius but not at 25 degree Celsius. tdp-1(ok803) reduce the lifespan of daf-2(e1370) mutants, but does not does not reduces the lifespan of daf-16(mu86) mutants. RNAi against tdp-1 reduces lifepsna of daf-2(e1370) mutants. tdp-1 overexpression strains have a reduced lifespan at 20 and 25 degree Celsius [Vaccaro et al. 2012]. | Nematode |
| Terf2 | telomeric repeat binding factor 2 | Overexpression results in signs of premature ageing. | House mouse |
| Trp53 | Transformation related protein 53 | Mice heterozyogous for an allele of p53 that removes the 5' portion of the protein demonstrate decreased cancer, permature aging phenotypes, and shortened lifespan in the mixed inbred C57BL/6â129/Sv background. It has been proposed that the this allele of p53 results in increased activity/overexpression [11780111]. Decreased activity of Trp53 results in increased cancer and decreased apoptosis. Mutant mice with activated Trp53 display enhanced resistance to spontaneous tumours and signs of premature ageing including reduced lifespan, osteoporosis, organ atrophy and a diminished stress tolerance [11780111]. However, super-p53 mice generate by a transgenic copy of a large genomic segment containing an intact and complete copy of p53 have an ehanced response to DNA damage, are significantly protected from cancer and had no indication of accelerated aging [12426394]. super-Ink4a/Arf/p53 mice have a synergic protection against cancer and delayed aging [Workshop RoSyBa 2011]. | House mouse |
| YDC1 | Yeast DihydroCeramidase 1 | Overexpression of YDC1 decreases chronological lifespan by 40% [19059240] | Budding yeast |
