Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
  • symbol name observation species
    MT-RNR2 An single nucleotide polymorphism in MT-RNR2 is associated with longevity [18759861]. Human
    PTK2 PTK2 was found to be associated with longevity [24930376]. PTK2 was not found to be associated with longevity [24930376]. Human
    PVRL2 PVRL2 was found to be associated with longevity [24924924]. PVRL2 was not found to be associated with longevity [24924924]. Human
    NOS2 NOS2 was found to be associated with longevity [23572278]. Human
    CYBA Human
    CDKN2B Human
    RAGE Human
    TP53 tumor protein p53 A naturally occuring allele with decreased p53 activity has been assoicated with extended survival [15732191].TP53 was found to be associated with longevity [23125046]. TP53 was found to be associated with longevity [18256523]. TP53 was found to be associated with longevity [15621215]. TP53 was found to be associated with longevity [18256523]. TP53 was not found to be associated with longevity [15195682]. TP53 was not found to be associated with longevity [15621215]. Human
    BDH1 3-hydroxybutyrate dehydrogenase, type 1 BDH1 was found to be associated with longevity [22445811]. Human
    NT5DC1 5'-nucleotidase domain containing 1 NT5DC1 was found to be associated with longevity [22279548]. Human
    MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 329 healthy individuals were examined for 2576A-->G (D919G) polymorphism in the MTR gene. Prevalence of the G-allele was significantly higher in the older than in the younger individuals. Separate analysis of female and male subjects revealed that the influence of the MTR genotype on male subjects became relevant at a younger age as opposed to female subjects suggesting a gender-dependent effect [16142417]. Human
    AKAP10 A kinase (PRKA) anchor protein 10 Male (n= 4766) and female (n = 6202) divided into young (183-9 years) and old (60 years) groups were examined for polymorphisms. A polymorphism that results in an amino acid change from Ile to Val showed the strongest correlation with age. The Val variant was associated with a statistically significant decrease in the length of the electrocardiogram PR interval. An A to G polymorphism in the 3'UTR of D-AKAP2 showed a significant decrease of the G allele in the older sample of both genders. Additionally, the I646V polymorphism was found to be significantly different between young and old in both males and females [12646697]. Human
    BAT5 abhydrolase domain containing 16A BAT5 was found to be associated with longevity [22279548]. Human
    ACPL2 acid phosphatase-like 2 ACPL2 was found to be associated with longevity [22445811]. Human
    ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 ADAMTS6 was found to be associated with longevity [22445811]. Human
    C9orf94 ADAMTS-like 1 C9orf94 was found to be associated with longevity [22279548]. Human
    ADA adenosine deaminase ADA was found to be associated with longevity [20174870]. ADA was found to be associated with longevity [21865054]. Human
    ADARB1 adenosine deaminase, RNA-specific, B1 ADARB1 was found to be associated with longevity [20011587]. Human
    ADARB2 adenosine deaminase, RNA-specific, B2 ADARB2 was found to be associated with longevity [20011587]. ADARB2 was not found to be associated with longevity [20011587]. Human
    ADCY2 adenylate cyclase 2 (brain) ADCY2 was found to be associated with longevity [19641380]. Human
    ADCY6 adenylate cyclase 6 ADCY6 was found to be associated with longevity [23020224]. Human
    ADIPQO adiponectin, C1Q and collagen domain containing ADIPQO was not found to be associated with longevity [20201642]. ADIPQO was found to be associated with longevity [20201642]. Human
    ADIPOQ10 adiponectin, C1Q and collagen domain containing ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [23339001]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was not found to be associated with longevity [18765803]. Human
    ART3 ADP-ribosyltransferase 3 ART3 was found to be associated with longevity [22445811]. Human
    ADRB2 adrenergic, beta-2-, receptor, surface ADRB2 was found to be associated with longevity [23020224]. ADRB2 was not found to be associated with longevity [23020224]. Human
    Factors are an extension of GenAge and GenDR.

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