| UCP1 | uncoupling protein 1 (mitochondrial, proton carrier) | UCP1 was found to be associated with longevity [21827845]. | Human |
| UCK2 | uridine-cytidine kinase 2 | UCK2 was found to be associated with longevity [22445811]. | Human |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | UCHL1 is assoicated with Parkinson's disease [9774100]. UCHL1 belongs to a family of de-ubiquitinating enzymes responsible for the hydrolysis of bonds between ubiquitin molecules and small adducts [11084366]. Decreased activity due to mutation may result in decreased labeling of abnormal proteins for clearance. | Human |
| UBE2H | ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) | UBE2H was found to be associated with longevity [22279548]. | Human |
| TXNRD1 | thioredoxin reductase 1 | TXNRD1 was found to be associated with longevity [22406557]. | Human |
| TXN | thioredoxin | Overexpression of TXN1 in transgenic C57BL/6 mice resulted in extended median (35%) and maximum (22%) lifespan. Telomerase activity in spleen tissues of TXN1 overexpressing mice is higher than tha in wild-type [12230882]. | Human |
| TUSC3 | tumor suppressor candidate 3 | TUSC3 was found to be associated with longevity [22279548]. | Human |
| TTC6 | tetratricopeptide repeat domain 6 | TTC6 was found to be associated with longevity [22279548]. | Human |
| TSPAN32 | tetraspanin 32 | TSPAN32 was found to be associated with longevity [19367319]. TSPAN32 was not found to be associated with longevity [19367319]. | Human |
| TSHR | thyroid stimulating hormone receptor | Two single nucleotide in the TSHR were associated with increased TSH in both centenarians and their offspring [19837933].TSHR was found to be associated with longevity [19837933]. TSHR was not found to be associated with longevity [19837933]. | Human |
| TSH-B | thyroid stimulating hormone, beta | TSH-B was found to be associated with longevity [19837933]. TSH-B was found to be associated with longevity [19837933]. | Human |
| TSA | Trichostatin A | Histone deacetylase inhibitor Trichostatin A (TSA) extends the lifespan of *Drosophila melanogaster* by promoting the hsp22 gene transcription, and affecting the chromatin morphology at the locus of hsp22 gene along the polytene chromosome [15346199].
hsp70 and hsp22 RNA levels are higher in long-lived than in short-lived fly lines. The HDAC inhibitor TSA causes a higher expression of hsp22 and hsp70, and strikingly influences the lifespan in both long and short-lived lines, with variable degrees (up to 25%) [15695762].
| Human |
| TRIM25 | tripartite motif containing 25 | TRIM25 was found to be associated with longevity [22279548]. | Human |
| TPO | thyroid peroxidase | TPO was not found to be associated with longevity [9050915]. | Human |
| TPI1 | triosephosphate isomerase 1 | TPI1 was not found to be associated with longevity [18510744]. | Human |
| TP53 | tumor protein p53 | A naturally occuring allele with decreased p53 activity has been assoicated with extended survival [15732191].TP53 was found to be associated with longevity [23125046]. TP53 was found to be associated with longevity [18256523]. TP53 was found to be associated with longevity [15621215]. TP53 was found to be associated with longevity [18256523]. TP53 was not found to be associated with longevity [15195682]. TP53 was not found to be associated with longevity [15621215]. | Human |
| TOX | thymocyte selection-associated high mobility group box | TOX was found to be associated with longevity [22279548]. | Human |
| TOMM40 | translocase of outer mitochondrial membrane 40 homolog (yeast) | TOMM440 correlates substantial with longevity and has been associated with Alzheimer's disease [22279548].
rs4420638 at TOMM40 gene locus exhibits significant association with longevity p-value = 9.6x10^-8). Combined modeling of linkage and association shows that association of longevity with APOEepsilon4 and APOEepsilon2 alleles explain the linkage at 19q1.11-q13.32 with pvalue-0.02 and p-value=1.0x10^-5, respectively [23286790]. TOMM40 was found to be associated with longevity [21418511; 23040522; 22279548]. TOMM40 was not found to be associated with longevity [24924924]. TOMM40 was found to be associated with longevity [24924924]. | Human |
| TNFSF8 | tumor necrosis factor (ligand) superfamily, member 8 | TNFSF8 was found to be associated with longevity [22279548]. | Human |
| TNFSF11 | tumor necrosis factor (ligand) superfamily, member 11 | TNFSF11 was not found to be associated with longevity [19641380]. | Human |
| TNFRSF11A | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | TNFRSF11A was found to be associated with longevity [22279548]. | Human |
| TNFb | tumor necrosis factor | TNFb was found to be associated with longevity [17989723]. | Human |
| TNFa | tumor necrosis factor | TNFa was found to be associated with longevity [17989723]. TNFA was not found to be associated with longevity [21865054]. | Human |
| TNF | tumor necrosis factor | The frequency of the -308 polymorphism in the TNF gene was analyzed in 71 healthy elders, aged 80 to 96 years (mean 86.2 years). The control samples were obtained from 99 young (from 21 - 54 years; mean 35.2 years) healthy individuals unrelated to elders were studied, age ranged from 80 to 96 years (mean 86.2 years). The TNF2 allele was increased in the elder group when compared to young controls [16269080].TNF was found to be associated with longevity [20518833]. TNF was found to be associated with longevity [18511747]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12676903]. TNF was found to be associated with longevity [11640949]. TNF was found to be associated with longevity [21299522]. TNF was found to be associated with longevity [21299522]. TNF was not found to be associated with longevity [12676903]. TNF was found to be associated with longevity [16269080]. TNF was not found to be associated with longevity [11640949]. | Human |
| TMEM61 | transmembrane protein 61 | TMEM61 was not found to be associated with longevity [21612516]. | Human |
