| zyg-11 | ZYGote defective: embryonic lethal | zyg-11 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| ZWINT | ZW10 interactor | ZWINT was found to be associated with longevity [22279548]. | Human |
| Zw | Zwischenferment | Mean lifespan of G6PD overexpressor flies is extended in comparison with driver and responder controls, armadillo-GAL4 (up to 38%), Tubulin-GAL4 (up to 29%), C23-GAL4 (up to 27%), da-GAL4 (up to 24%), D42-GAL4 (up to 18%) and Appl-GAL4 (up to 16%). The maximum lifespan is also increased [18809674].
G6PD enzymatic activity as well as levels of NADPH, NADH, and the GSH/GSSG ration are increased [18809674]. | Fruit fly |
| ztf-12 | Zinc finger Transcription Factor family | RNA interference of ztf-12 results in a shortened lifespan. ztf-12 is a target of daf-16 [16380712]. | Nematode |
| ZTA1 | Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity | Deletion of ZTA1 increases replicative lifespan by 15% in the alpha strain and decreased by 10% in the a strain [18340043]. Although ZTA1 was identified as a potential long-lived mutant strain in a bar-code screen, deletion of ZTA1 does not significantly affect chronological lifespan under starvation/extreme DR [20657825]. | Budding yeast |
| ZNF331 | zinc finger protein 331 | ZNF331 was found to be associated with longevity [21782286]. | Human |
| Zmpste24 | zinc metallopeptidase, STE24 homolog (S. cerevisiae) | Knockout mice exhibit nuclear architecture abnormalities and signs of accelerated ageing. | House mouse |
| ZK809.3 | — | RNA interference increased mean lifespan by 100%. | Nematode |
| ZK686.2 | — | RNA interference in adulthood extended mean lifespan by 24%. | Nematode |
| ZK1127.5 | — | RNA interference in adulthood extended mean lifespan by 24%. | Nematode |
| ZIP1 | Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate | Replicative lifespan decreased by 30% in the a strain | Budding yeast |
| zfp-1 | Zinc Finger Protein | RNA interference shortened lifespan. | Nematode |
| ZDS2 | Zillion Different Screens 2 | Deletion of ZDS2 decreases replicative lifespan by about 20% [10662670].
ZDS2 null mutation decreases rDNA silencing five-fold, increases silencing at a mutant HMR that lacks the Rap1-binding site in the HNR-E silencer three-fold, and has no effect on telomeric silencing. ZDS2 deletion decreases rDNA silencing, increases rDNA recombination, and increases level of phosphorylated Sir3 [10662670].
| Budding yeast |
| ZDS1 | Zillion Different Screens 1 | Deletion of ZDS1 increases replicative lifespan by 37% in a SIR3-dependent manner [10662670].
Null mutation in ZDS1 causes 100-fold decrease in telomeric silencing, a nine-fold increase in rDNA silencing, reduces rDNA recombination, and decreases Sir3 phosphorylation [10662670]. | Budding yeast |
| ZC395.10 | Zinc finger Transcription Factor family | ZC395.10 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| ZC250.3 | — | RNA interference decreased median lifespan by 29% in wild type animals, 41% in a daf-2 background and 25% in daf-2/daf-16 double mutants. | Nematode |
| ZC132.3 | — | RNA interference in adulthood extended mean lifespan by 26%. | Nematode |
| ZBTB20 | zinc finger and BTB domain containing 20 | ZBTB20 was found to be associated with longevity [22279548]. | Human |
| YVH1 | Yeast vaccinia virus VH1 Homolog 1 | Deletion of YVH1 increases replicative lifespan by 50% in the alpha strain [18340043]. | Budding yeast |
| YUH1 | Yeast Ubiquitin Hydrolase 1 | Deletion of YUH1 decreases replicative lifespan decreased 30% in the alpha strain [18340043]. | Budding yeast |
| YTHDF2 | YTH domain family, member 2 | A locus associated with human longevity corresponds to (TG)n microsatellite is located in the YTHDF2 gene. 412 participants of different ages, including 137 centenarians, were genotyped. The increased homozygosity in centenarians at this locus was confirmed, and observed a concomitantly increased frequency of the most frequent allele and the corresponding homozygous genotype. The same genotype was associated with increased YTHDF2 messenger RNA levels in immortalized lymphocytes. [16799135].YTHDF2 was found to be associated with longevity [16799135]. | Human |
| YSC84 | — | Deletion of YSC84 increases replicative lifespan by 20% in the alpha strain [19030232]. YSC84 deletion increases replicative lifespan by 25% in the alpha strain [18340043]. | Budding yeast |
| yrs-1 | tYrosinyl tRNA Synthetase | RNA interference increased mean lifespan by 55%. | Nematode |
| YPT7 | Yeast Protein Two 7 | YPT7 deletion decreases replicative lifespan by 15% in the alpha strain [18340043]. Deletion of YPT7 cancels out replicative lifespan extension of 0.5% glucose restriction and results under DR also into a shorter replicative lifespan than under AL [18690010]. | Budding yeast |
| YPT6 | Yeast Protein Two 6 | Deletion of YPT6 increases replicative lifespan by 20% [19030232]. YPT6 deletion increases replicative lifespan by 30% in the alpha strain and by 10% in the a strain [18340043]. | Budding yeast |
