| ZWINT | ZW10 interactor | ZWINT was found to be associated with longevity [22279548]. | Human |
| ZNF331 | zinc finger protein 331 | ZNF331 was found to be associated with longevity [21782286]. | Human |
| ZBTB20 | zinc finger and BTB domain containing 20 | ZBTB20 was found to be associated with longevity [22279548]. | Human |
| YTHDF2 | YTH domain family, member 2 | A locus associated with human longevity corresponds to (TG)n microsatellite is located in the YTHDF2 gene. 412 participants of different ages, including 137 centenarians, were genotyped. The increased homozygosity in centenarians at this locus was confirmed, and observed a concomitantly increased frequency of the most frequent allele and the corresponding homozygous genotype. The same genotype was associated with increased YTHDF2 messenger RNA levels in immortalized lymphocytes. [16799135].YTHDF2 was found to be associated with longevity [16799135]. | Human |
| YBX2 | Y box binding protein 2 | — | Human |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | The single-nucleotide polymorphism in rs132793 in XRCC6 has significant effect on telomere length, but it is not associated with longevity [21972126]. | Human |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | XRCC5 was found to be associated with longevity [22406557; 16518718]. | Human |
| XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 | XRCC4 was found to be associated with longevity [16518718]. | Human |
| XRCC3 | X-ray repair complementing defective repair in Chinese hamster cells 3 | XRCC3 was found to be associated with longevity [16518718]. | Human |
| XRCC1 | X-ray repair complementing defective repair in Chinese hamster cells 1 | XRCC1 was found to be associated with longevity [16518718]. | Human |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | XKR6 was found to be associated with longevity [22279548]. | Human |
| XDH | xanthine dehydrogenase | XDH was found to be associated with longevity [22406557; 22279548]. | Human |
| WWOX | WW domain containing oxidoreductase | WWOX was found to be associated with longevity [22279548]. WWOX was found to be associated with longevity [24244950]. | Human |
| WRN | Werner syndrome, RecQ helicase-like | Mutation in WRN causes Werner Syndrome which characteristics includes prematurely aged facies, scleroderma-like skin changes, cataracts, arteriosclerosis, subcutaneous calcification, and diabetes mellitus [McKusick et al. 1963; 5327241]. Inheritance is autosomal recessive and malignancy is frequent. THe frequency is 3 per million individuals in Japan [7460386].
Cells from a Werner heterozygote exit the cell cycle at a faster rate than do normal cells [8265666]. Loss of WRN promoter aberrant mitotic recombination [11316787].
The single nucleotide polymorphism rs1800392 in WRN has been associated with exceptional longevity in a plethora of genetic signatures [22279548]. WRN was found to be associated with longevity [10069711; 20855428; 20855428; 20855428 ;17903295; 22406557; 16405962; 16405962; 16405962; 20855428; 20855428; 20855428; 22279548]. WRN was found to be associated with longevity [24244950]. | Human |
| WDR72 | WD repeat domain 72 | WDR72 was found to be associated with longevity [22279548]. | Human |
| VWA5A | von Willebrand factor A domain containing 5A | VWA5A was found to be associated with longevity [21782286]. | Human |
| VPS13D | vacuolar protein sorting 13 homolog D (S. cerevisiae) | VPS13D was found to be associated with longevity [22279548]. | Human |
| Vitamin D receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | Vitamin D receptor was not found to be associated with longevity [21051524]. | Human |
| VEGFA | vascular endothelial growth factor A | VEGFA was found to be associated with longevity [17574707]. VEGFA was not found to be associated with longevity [17574707]. | Human |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | VDR was found to be associated with longevity [21051524]. VDR was not found to be associated with longevity [20407924]. VDR was found to be associated with longevity [20407924]. | Human |
| VASH1 | vasohibin 1 | VASH1 was found to be associated with longevity [22279548]. | Human |
| upstream of FOXO3A | — | upstream of FOXO3A was found to be associated with longevity [19196970]. | Human |
| Upstram of FOXO3A | — | Upstram of FOXO3A was found to be associated with longevity [19196970]. | Human |
| UCP3 | uncoupling protein 3 (mitochondrial, proton carrier) | UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. | Human |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | Overexpression of human UCP2 in the fly nervous system extends lifespan by 10-30%. Ubiquitous overexpression is lethal [16054055]. | Human |
