Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
  • symbol name observation species
    zyg-11 ZYGote defective: embryonic lethal zyg-11 RNAi in the adulthood extends the lifespan [New longevity regulators]. Nematode
    ztf-12 Zinc finger Transcription Factor family RNA interference of ztf-12 results in a shortened lifespan. ztf-12 is a target of daf-16 [16380712]. Nematode
    ZK809.3 RNA interference increased mean lifespan by 100%. Nematode
    ZK686.2 RNA interference in adulthood extended mean lifespan by 24%. Nematode
    ZK1127.5 RNA interference in adulthood extended mean lifespan by 24%. Nematode
    zfp-1 Zinc Finger Protein RNA interference shortened lifespan. Nematode
    ZC395.10 Zinc finger Transcription Factor family ZC395.10 RNAi in the adulthood extends the lifespan [New longevity regulators]. Nematode
    ZC250.3 RNA interference decreased median lifespan by 29% in wild type animals, 41% in a daf-2 background and 25% in daf-2/daf-16 double mutants. Nematode
    ZC132.3 RNA interference in adulthood extended mean lifespan by 26%. Nematode
    yrs-1 tYrosinyl tRNA Synthetase RNA interference increased mean lifespan by 55%. Nematode
    Y77E11A.7 Y77E11A.7b RNA interference decreased median lifespan by 24% in wild type animals, 40% in a daf-2 background and 13% in daf-2/daf-16 double mutants. Nematode
    Y75B8A.33 RNA interference extends lifespan. Nematode
    Y75B8A.13 RNA interference extends lifespan. Nematode
    Y71H2AR.2 RNA interference extends lifespan. Nematode
    Y71G12B.4 RNA interference extends lifespan. Nematode
    Y69A2AR.19 RNA interference increased mean lifespan by 19%. Nematode
    Y65B4BR.5 RNA interference in adulthood extended mean lifespan by 17%. Nematode
    Y65B4A.3 RNA interference decreased median lifespan by 71% in a daf-2 background and 35% in daf-2/daf-16 double mutants. Nematode
    Y59A8B.2 RNA interference decreased median lifespan by 59% in daf-2 mutants. Nematode
    Y56A3A.9 Y56A3A.9 RNA interference extends lifespan. Nematode
    Y56A3A.19 RNA interference in adulthood extended mean lifespan by 21%. Nematode
    Y55F3AM.3 RNA interference decreased median lifespan by 9% in wild type animals and 21% in daf-2 mutants. Nematode
    Y54E5A.7 RNA interference extends lifespan. Nematode
    Y54E10BR.4 RNA interference in adulthood extended mean lifespan by 15%. Nematode
    Y53F4B.23 RNA interference extends lifespan. Nematode
    • Page 1 of 35
    • 25 of 864 factors
    Factors are an extension of GenAge and GenDR.

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