| URE2 | UREidosuccinate transport 2 | Deletion of URE2 increase mean replicative lifespan by 21-31% in BY4742 [16293764]. URE2 deletion increases replicative lifespan increased by 20% in the alpha strain [19030232]. | Budding yeast |
| unc-76 | UNCoordinated | unc-76(e911) allele extends male lifespan by about 50%, but has no effect on hermaphrodite lifespan [10747056].
unc-76 mutants are uncoordinated [4366476]. | Nematode |
| unc-64 | UNCoordinated | Mutations in unc-64 result in constitutive dauer formation and increase lifespan, which is suppressed by mutations in daf-16 [10377425]. unc-64 mutation increases mean and maximum lifespan [16280150]. unc-64 mutation increased lifespan of hermaphrodites by approximately 70% and those of males by 150% [10377425; 4366476; 10747056].
unc-64 mutants are uncoordinated [4366476]. | Nematode |
| unc-52 | UNCoordinated 52 | RNA interference of unc-52 in adulthood extends mean lifespan by 11% [17411345]. RNAi knockdown of unc-52 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. UNC-52 levels are elevated in eat-2 mutants. Increased content of UNC-52 is, at least partially, required for lifespan-extension by DR [22810224]. | Nematode |
| unc-4 | UNCoordinated | Lifespan of unc-4(e120) males is extended relative to hermaphrodites approximately 2-fold [10747056]. Mutation in unc-4 has no significant effect on hermaphrodite lifespan [9789046].
unc-4 mutants are uncoordinated [4366476]. | Nematode |
| unc-32 | UNCoordinated | unc-32 mutation extends male lifespan by about 170%, but has no effect on hermaphrodite lifespan [10747056].
unc-31 mutants are uncoordinated [4366476]. | Nematode |
| unc-26 | UNCoordinated | Mutations in unc-26 extend lifespan by 30-50%. Lifespan extension is proposed to be similar to DR [9789046].
unc-26 mutants are uncoordinated, slow and have defects in pharyngeal pumping [4366476; 8462849]. | Nematode |
| unc-17 | UNCoordinated 17 | unc-17 encodes acteylcholine transporter which is expressed in motor [18041778] and inter-neurons and is downregulated in space. Mutation of unc-17 extends lifespan on NGM agar covered with killed or live bacteria. nc-17(CB933) extends mean, 75%ile, and maximum lifespan by 31-79%, 68-89%, and 68-79%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of daf-16, but not skn-1. eat-2 RNAi further enhances the extension of lifespan by mutations of unc-17 [22768380].
Mutation and RNAi of unc-17 suppresses pheromone-induced dauer formation [22768380].
| Nematode |
| unc-13 | UNCoordinated | Mutation in unc-13 results in a 150% life-extension in males, but has no effect on hermaphrodite lifespan [10747056]. | Nematode |
| UGA3 | Utilization of GAba 3 | Deletion of UGA3 increases mean and maximum replicative lifespan by 75% and 63%, respectively [20550517] | Budding yeast |
| UGA1 | Utilization of GAba 1 | Deletion of UGA2 extends replicative lifespan [21371425]. | Budding yeast |
| ucr-1 | Ubiquinol-Cytochrome c oxidoReductase complex | RNAi against ucr-1 increases mean lifespan by 20% [17608836]. ucr-1 RNAi started after the animal reached the late L4 stage increase mean lifespan by 8-14% [22103665]. | Nematode |
| ubh-4 | UBiquitin C-terminal Hydrolase (family 1) | RNAi of ubh-4 starting at L1 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. | Nematode |
| tub-1 | TUBby-related | Mutation of tub-1 (alleles nr2004 and nr2044) leads to 20-25% life-extension dependent on daf-16 [16054097].
tub-1 mutation promotes increased fat accumulation [16054097]. | Nematode |
| ttr-5 | — | RNA interference of ttr-5 increase mean lifespan 14% [17608836]. | Nematode |
| ttll-9 | Tubulin Tyrosine Ligase Like | Knockdown of ttll-9 throughout the entire life increases the lifespan by 3% [23698443]. | Nematode |
| TSL1 | Trehalose Synthase Long chain 1 | Deletion of TSL1 extends the mean chronological lifespan by 43% (at 30 degree Celsus in BY4742) [22783207].
Mutant TSL1 cells have reduced oxidative carbonylation of cellular proteins throughout lifespan. TSL1 mutants have higher trehalose levels, but reaches a plateau at the level of 50-70% of wild-type in the stationary phase. TSL1 deletion cells have no altered ROS levels in pre-quiescent cells [22783207]. | Budding yeast |
| Trp53 | Transformation related protein 53 | Mice heterozyogous for an allele of p53 that removes the 5' portion of the protein demonstrate decreased cancer, permature aging phenotypes, and shortened lifespan in the mixed inbred C57BL/6â129/Sv background. It has been proposed that the this allele of p53 results in increased activity/overexpression [11780111]. Decreased activity of Trp53 results in increased cancer and decreased apoptosis. Mutant mice with activated Trp53 display enhanced resistance to spontaneous tumours and signs of premature ageing including reduced lifespan, osteoporosis, organ atrophy and a diminished stress tolerance [11780111]. However, super-p53 mice generate by a transgenic copy of a large genomic segment containing an intact and complete copy of p53 have an ehanced response to DNA damage, are significantly protected from cancer and had no indication of accelerated aging [12426394]. super-Ink4a/Arf/p53 mice have a synergic protection against cancer and delayed aging [Workshop RoSyBa 2011]. | House mouse |
| TRM9 | TRna Methyltransferase 9 | TRM9 deletion almost triples mean chronological lifespan under starvation/extreme DR, increases heat resistance, but reduces resistance to acetic acid. Similar effect were present in the BY746 background in SDC medium [20657825]. | Budding yeast |
| trim-9 | TRIpartite Motif-containing protein homolog 9 | RNA interference of trim-9 extends lifespan [15998808]. | Nematode |
| TPS3 | Trehalose-6-Phosphate Synthase 3 | Deletion of TPS3 extend the mean chronological lifespan by 39% (at 30 degree Celsus in BY4742) [22783207].
TPS3 mutants have higher trehalose levels until the end of the post-diauxic growth phase, but reaches a plateau at the level of 50-70% of wild-type in the stationary phase [22783207]. | Budding yeast |
| TOS8 | Target Of Sbf 8 | Deletion of TOS8 increases replicative lifespan increased by 35% in the alpha strain [18340043]. | Budding yeast |
| TOR1 | Target Of Rapamycin 1 | TOR1 deletion extends mean and maximum replicative lifespan by 21 and 25% [16293764] as well as chronological lifespan [21076178]. This lifespan extension is independent of SIR2 and additive with deletion of FOB1 [16293764]. Deletion of TOR1 fails to increase the replicative lifespan of a sir2 mutant [20947565]. Deletion of TOR1 substantially extends chronological lifespan, increasing median survival almost 3-fold (wild-type 4.5 days, tor1 null 12 days), i.e. by 167%. By 21 days in culture, the vast majority of wild-type cells had died (>99.9%), whereas many tor1 null cells remained viable. Deletion of TOR1 also extends the chronological lifespan of the relatively short-lived BY4742 strain, one of the two haploid genetic backgrounds of the widely used Yeast Knockout Collection available from Open Biosystems. Deletion of TOR1 fails to extend chronological lifespan in Petite strains that are unable to respire [17403371]. TOR1 deletion increases replicative lifespan by 30% in the alpha strain and 20% in a strain [19030232]. TOR1 deletion mutant have and increased mean and maximum replicative lifespan by 21% and 6%, respectively [21931558]. Deletion of TOR1 extends replicative lifespan as well as chronological lifespan [21076178] and glucose restriction fails to further extend the long replicative lifespan of tor1Delta [16293764; 16418483; 18225956]. Water starvation (extreme DR) further extends chronological lifespan of tor1 mutants [18225956]. | Budding yeast |
| Tor | Target of rapamycin | Expression of a dominant-negative form of Tor extends lifespan [15186745]. Ubiquitious overexpression of dTOR with the da-GAL4 driver of UAS-dTOR(FRB) which contains the 11kDA FKB12-rapamycin binding domain led to a mean and maximum lifespan increase of 15% (24%) and 29% at 29°C and of 50% (26%) and 13% at 25°C, respectively [15186745].
Overexpression of the dominant-negative form of Tor specifically in the fat and muscle tissues is sufficient to extend the mean and maximum lifespan by 24 and 19%, respectively [15186745].
Overexpression of UAS-dTOR(WT) or UAS-dTOR(TED) prevents eclosion to adulthood [15186745]. | Fruit fly |
| TMA19 | Translation Machinery Associated 19 | Deletion of TMA19 increases replicative lifespan by 16% (P<0.02) [16806052]. TMA19 deletion increases replicative lifespan by 25-30% in the alpha and a strains [19030232].
| Budding yeast |
