| UBE2H | ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) | UBE2H was found to be associated with longevity [22279548]. | Human |
| Ubash3b | ubiquitin-associated and SH3 domain-containing protein B | Ubash3b is transcriptional downregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| U4 | U4 spliceosomal RNA | U4 is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| Txnrd1 | Thioredoxin reductase 1, cytoplasmic | Txnrd1 is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| TXNRD1 | thioredoxin reductase 1 | TXNRD1 was found to be associated with longevity [22406557]. | Human |
| TUSC3 | tumor suppressor candidate 3 | TUSC3 was found to be associated with longevity [22279548]. | Human |
| TTC6 | tetratricopeptide repeat domain 6 | TTC6 was found to be associated with longevity [22279548]. | Human |
| TSPAN32 | tetraspanin 32 | TSPAN32 was found to be associated with longevity [19367319]. TSPAN32 was not found to be associated with longevity [19367319]. | Human |
| TSHR | thyroid stimulating hormone receptor | Two single nucleotide in the TSHR were associated with increased TSH in both centenarians and their offspring [19837933].TSHR was found to be associated with longevity [19837933]. TSHR was not found to be associated with longevity [19837933]. | Human |
| TSH-B | thyroid stimulating hormone, beta | TSH-B was found to be associated with longevity [19837933]. TSH-B was found to be associated with longevity [19837933]. | Human |
| TRIM25 | tripartite motif containing 25 | TRIM25 was found to be associated with longevity [22279548]. | Human |
| TP53 | tumor protein p53 | A naturally occuring allele with decreased p53 activity has been assoicated with extended survival [15732191].TP53 was found to be associated with longevity [23125046]. TP53 was found to be associated with longevity [18256523]. TP53 was found to be associated with longevity [15621215]. TP53 was found to be associated with longevity [18256523]. TP53 was not found to be associated with longevity [15195682]. TP53 was not found to be associated with longevity [15621215]. | Human |
| TOX | thymocyte selection-associated high mobility group box | TOX was found to be associated with longevity [22279548]. | Human |
| TOMM40 | translocase of outer mitochondrial membrane 40 homolog (yeast) | TOMM440 correlates substantial with longevity and has been associated with Alzheimer's disease [22279548].
rs4420638 at TOMM40 gene locus exhibits significant association with longevity p-value = 9.6x10^-8). Combined modeling of linkage and association shows that association of longevity with APOEepsilon4 and APOEepsilon2 alleles explain the linkage at 19q1.11-q13.32 with pvalue-0.02 and p-value=1.0x10^-5, respectively [23286790]. TOMM40 was found to be associated with longevity [21418511; 23040522; 22279548]. TOMM40 was not found to be associated with longevity [24924924]. TOMM40 was found to be associated with longevity [24924924]. | Human |
| TNFSF8 | tumor necrosis factor (ligand) superfamily, member 8 | TNFSF8 was found to be associated with longevity [22279548]. | Human |
| TNFRSF11A | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | TNFRSF11A was found to be associated with longevity [22279548]. | Human |
| TNFb | tumor necrosis factor | TNFb was found to be associated with longevity [17989723]. | Human |
| TNFa | tumor necrosis factor | TNFa was found to be associated with longevity [17989723]. TNFA was not found to be associated with longevity [21865054]. | Human |
| TNF | tumor necrosis factor | The frequency of the -308 polymorphism in the TNF gene was analyzed in 71 healthy elders, aged 80 to 96 years (mean 86.2 years). The control samples were obtained from 99 young (from 21 - 54 years; mean 35.2 years) healthy individuals unrelated to elders were studied, age ranged from 80 to 96 years (mean 86.2 years). The TNF2 allele was increased in the elder group when compared to young controls [16269080].TNF was found to be associated with longevity [20518833]. TNF was found to be associated with longevity [18511747]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12676903]. TNF was found to be associated with longevity [11640949]. TNF was found to be associated with longevity [21299522]. TNF was found to be associated with longevity [21299522]. TNF was not found to be associated with longevity [12676903]. TNF was found to be associated with longevity [16269080]. TNF was not found to be associated with longevity [11640949]. | Human |
| Tmem218 | Transmembrane protein 218 | Tmem218 is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| TMEM2 | transmembrane protein 2 | TMEM2 was found to be associated with longevity [22279548]. | Human |
| TLR4 | toll-like receptor 4 | The ASP299GLY ploymorphism in the TLR4 gene shows a significantly lower frequency in patients affected by myocardial infarction compared to controls, whereas centenarians exhibit a higher frequency [16803999]. TLR4 was found to be associated with longevity [16803999; 17493663].TLR4 was found to be associated with longevity [17493663]. TLR4 was not found to be associated with longevity [17493663]. | Human |
| Thrsp | Thyroid hormone-inducible hepatic protein | Thrsp is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| THO, mtDNA | THO complex 1 | THO, mtDNA was found to be associated with longevity [11053670]. | Human |
| THO | THO complex 1 | THO was found to be associated with longevity [9887369]. | Human |
