| ZWINT | ZW10 interactor | ZWINT was found to be associated with longevity [22279548]. | Human |
| ZNF331 | zinc finger protein 331 | ZNF331 was found to be associated with longevity [21782286]. | Human |
| ZBTB20 | zinc finger and BTB domain containing 20 | ZBTB20 was found to be associated with longevity [22279548]. | Human |
| YTHDF2 | YTH domain family, member 2 | A locus associated with human longevity corresponds to (TG)n microsatellite is located in the YTHDF2 gene. 412 participants of different ages, including 137 centenarians, were genotyped. The increased homozygosity in centenarians at this locus was confirmed, and observed a concomitantly increased frequency of the most frequent allele and the corresponding homozygous genotype. The same genotype was associated with increased YTHDF2 messenger RNA levels in immortalized lymphocytes. [16799135].YTHDF2 was found to be associated with longevity [16799135]. | Human |
| Yaf2 | YY1 associated factor 2 | Yaf2 is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | XRCC5 was found to be associated with longevity [22406557; 16518718]. | Human |
| XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 | XRCC4 was found to be associated with longevity [16518718]. | Human |
| XRCC3 | X-ray repair complementing defective repair in Chinese hamster cells 3 | XRCC3 was found to be associated with longevity [16518718]. | Human |
| XRCC1 | X-ray repair complementing defective repair in Chinese hamster cells 1 | XRCC1 was found to be associated with longevity [16518718]. | Human |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | XKR6 was found to be associated with longevity [22279548]. | Human |
| XDH | xanthine dehydrogenase | XDH was found to be associated with longevity [22406557; 22279548]. | Human |
| WWOX | WW domain containing oxidoreductase | WWOX was found to be associated with longevity [22279548]. WWOX was found to be associated with longevity [24244950]. | Human |
| WRN | Werner syndrome, RecQ helicase-like | Mutation in WRN causes Werner Syndrome which characteristics includes prematurely aged facies, scleroderma-like skin changes, cataracts, arteriosclerosis, subcutaneous calcification, and diabetes mellitus [McKusick et al. 1963; 5327241]. Inheritance is autosomal recessive and malignancy is frequent. THe frequency is 3 per million individuals in Japan [7460386].
Cells from a Werner heterozygote exit the cell cycle at a faster rate than do normal cells [8265666]. Loss of WRN promoter aberrant mitotic recombination [11316787].
The single nucleotide polymorphism rs1800392 in WRN has been associated with exceptional longevity in a plethora of genetic signatures [22279548]. WRN was found to be associated with longevity [10069711; 20855428; 20855428; 20855428 ;17903295; 22406557; 16405962; 16405962; 16405962; 20855428; 20855428; 20855428; 22279548]. WRN was found to be associated with longevity [24244950]. | Human |
| WDR72 | WD repeat domain 72 | WDR72 was found to be associated with longevity [22279548]. | Human |
| VWA5A | von Willebrand factor A domain containing 5A | VWA5A was found to be associated with longevity [21782286]. | Human |
| VPS13D | vacuolar protein sorting 13 homolog D (S. cerevisiae) | VPS13D was found to be associated with longevity [22279548]. | Human |
| VEGFA | vascular endothelial growth factor A | VEGFA was found to be associated with longevity [17574707]. VEGFA was not found to be associated with longevity [17574707]. | Human |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | VDR was found to be associated with longevity [21051524]. VDR was not found to be associated with longevity [20407924]. VDR was found to be associated with longevity [20407924]. | Human |
| VASH1 | vasohibin 1 | VASH1 was found to be associated with longevity [22279548]. | Human |
| upstream of FOXO3A | — | upstream of FOXO3A was found to be associated with longevity [19196970]. | Human |
| Upstram of FOXO3A | — | Upstram of FOXO3A was found to be associated with longevity [19196970]. | Human |
| Ucp3 | uncoupling protein 3 (mitochondrial, proton carrier) | Metabolic intensity (daily food energy/body mass) correlates with longevity in MF1 mice. The animals with the highest quartile of metabolic intensities have a mean lifespan of 36% longer than animals with the lowest quartile of metabolic intensities. The highest metabolism of long-lived animals can be attributed to increased uncoupling Ucp3 [15153176].
Skeletal muscle mitochondria isolated from high metabolism mice are more uncoupled that those from low metabolism mice [15153176]. | House mouse |
| UCP3 | uncoupling protein 3 (mitochondrial, proton carrier) | UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. | Human |
| UCP1 | uncoupling protein 1 (mitochondrial, proton carrier) | UCP1 was found to be associated with longevity [21827845]. | Human |
| UCK2 | uridine-cytidine kinase 2 | UCK2 was found to be associated with longevity [22445811]. | Human |
