| ZDS1 | Zillion Different Screens 1 | Deletion of ZDS1 increases replicative lifespan by 37% in a SIR3-dependent manner [10662670].
Null mutation in ZDS1 causes 100-fold decrease in telomeric silencing, a nine-fold increase in rDNA silencing, reduces rDNA recombination, and decreases Sir3 phosphorylation [10662670]. | Budding yeast |
| UTH1 | yoUTH 1 | Mutation in UTH1 increases replicative lifespan by approximately 15% [7859289].
UTH1 mutant has enhanced stress resistance to cold stress [7859289], heat shock [10870102], starvation [7859289], hydrogen peroxide, but is sensitive to paraquat and oxygen [9799359]. | Budding yeast |
| YVH1 | Yeast vaccinia virus VH1 Homolog 1 | Deletion of YVH1 increases replicative lifespan by 50% in the alpha strain [18340043]. | Budding yeast |
| YPT6 | Yeast Protein Two 6 | Deletion of YPT6 increases replicative lifespan by 20% [19030232]. YPT6 deletion increases replicative lifespan by 30% in the alpha strain and by 10% in the a strain [18340043]. | Budding yeast |
| YDC1 | Yeast DihydroCeramidase 1 | Overexpression of YDC1 decreases chronological lifespan by 40% [19059240] | Budding yeast |
| bub-3 | yeast BUB homolog | RNAi against bub-3 increases mean and maximum lifespan by 6-7% and 7%, respectively [18059442]. | Nematode |
| WRKY6 | WRKY transcription factor 6 | Deletion of the WRKY6 promoter results in defects in root and leaf cell senescence [11722756].
WRKY6 is a transcription factor involved in controlling processes related to senescence and pathogen defence [11722756] and is a positive regulator of PR1 expression [12000796]. WRKY6 is strongly expressed during senescence [11722756]. | — |
| wah-1 | Worm AIF (apoptosis inducing factor) Homolog | wah-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. RNAi against wah-1 started after the animal reaches the late L4 stage extends mean lifespan by 7-8% [22103665]. | Nematode |
| wdr-23 | WD Repeat protein 23 | RNA interference of wdr-23 in adulthood extends mean lifespan by 24% [17411345]. | Nematode |
| wts-1 | WarTS (Drosophila) protein kinase homolog 1 | RNA interference of wts-1 in adulthood extends mean lifespan by 21% [17411345]. | Nematode |
| vit-5 | VITellogenin structural genes (yolk protein genes) 5 | RNA interference against vit-5 extends mean lifespan by 10-22%. vit-5 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331]. RNAi knockdown of vit-5 starting at hatching or only during the adulthood significantly extends lifespan of wild-type, but does not alter, or even shortens the lifespan of eat-2 mutants [22810224]. | Nematode |
| vit-2 | VITellogenin structural genes (yolk protein genes) | vit-2 RNA interference extends mean lifespan by 21-24%. vit-2 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331].
vit-2 functions in germ-line development by regulating the abundance of native versus oxidized LDL-like lipoproteins [11408580]. | Nematode |
| VBA5 | Vacuolar Basic Amino acid transporter 5 | Deletion of of VBA5 increases replicative lifespan by 31% [16293764]. | Budding yeast |
| UGA3 | Utilization of GAba 3 | Deletion of UGA3 increases mean and maximum replicative lifespan by 75% and 63%, respectively [20550517] | Budding yeast |
| UGA1 | Utilization of GAba 1 | Deletion of UGA2 extends replicative lifespan [21371425]. | Budding yeast |
| URE2 | UREidosuccinate transport 2 | Deletion of URE2 increase mean replicative lifespan by 21-31% in BY4742 [16293764]. URE2 deletion increases replicative lifespan increased by 20% in the alpha strain [19030232]. | Budding yeast |
| unc-52 | UNCoordinated 52 | RNA interference of unc-52 in adulthood extends mean lifespan by 11% [17411345]. RNAi knockdown of unc-52 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. UNC-52 levels are elevated in eat-2 mutants. Increased content of UNC-52 is, at least partially, required for lifespan-extension by DR [22810224]. | Nematode |
| unc-17 | UNCoordinated 17 | unc-17 encodes acteylcholine transporter which is expressed in motor [18041778] and inter-neurons and is downregulated in space. Mutation of unc-17 extends lifespan on NGM agar covered with killed or live bacteria. nc-17(CB933) extends mean, 75%ile, and maximum lifespan by 31-79%, 68-89%, and 68-79%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of daf-16, but not skn-1. eat-2 RNAi further enhances the extension of lifespan by mutations of unc-17 [22768380].
Mutation and RNAi of unc-17 suppresses pheromone-induced dauer formation [22768380].
| Nematode |
| unc-26 | UNCoordinated | Mutations in unc-26 extend lifespan by 30-50%. Lifespan extension is proposed to be similar to DR [9789046].
unc-26 mutants are uncoordinated, slow and have defects in pharyngeal pumping [4366476; 8462849]. | Nematode |
| unc-32 | UNCoordinated | unc-32 mutation extends male lifespan by about 170%, but has no effect on hermaphrodite lifespan [10747056].
unc-31 mutants are uncoordinated [4366476]. | Nematode |
| unc-4 | UNCoordinated | Lifespan of unc-4(e120) males is extended relative to hermaphrodites approximately 2-fold [10747056]. Mutation in unc-4 has no significant effect on hermaphrodite lifespan [9789046].
unc-4 mutants are uncoordinated [4366476]. | Nematode |
| unc-13 | UNCoordinated | Mutation in unc-13 results in a 150% life-extension in males, but has no effect on hermaphrodite lifespan [10747056]. | Nematode |
| unc-64 | UNCoordinated | Mutations in unc-64 result in constitutive dauer formation and increase lifespan, which is suppressed by mutations in daf-16 [10377425]. unc-64 mutation increases mean and maximum lifespan [16280150]. unc-64 mutation increased lifespan of hermaphrodites by approximately 70% and those of males by 150% [10377425; 4366476; 10747056].
unc-64 mutants are uncoordinated [4366476]. | Nematode |
| unc-76 | UNCoordinated | unc-76(e911) allele extends male lifespan by about 50%, but has no effect on hermaphrodite lifespan [10747056].
unc-76 mutants are uncoordinated [4366476]. | Nematode |
| ubh-4 | UBiquitin C-terminal Hydrolase (family 1) | RNAi of ubh-4 starting at L1 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. | Nematode |
