Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    LRP1B low density lipoprotein receptor-related protein 1B LRP1B was found to be associated with longevity [22279548]. Human
    NT5DC1 5'-nucleotidase domain containing 1 NT5DC1 was found to be associated with longevity [22279548]. Human
    ZBTB20 zinc finger and BTB domain containing 20 ZBTB20 was found to be associated with longevity [22279548]. Human
    PITPNM3 PITPNM family member 3 PITPNM3 was found to be associated with longevity [22279548]. Human
    NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 NFKB1 was found to be associated with longevity [22279548]. Human
    SLC6A7 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 SLC6A7 was found to be associated with longevity [22279548]. SLC6A7 was found to be associated with longevity [24244950]. Human
    SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4 SLC4A4 was found to be associated with longevity [22279548]. Human
    PLEKHA7 pleckstrin homology domain containing, family A member 7 PLEKHA7 was found to be associated with longevity [22279548]. Human
    GATA4 GATA binding protein 4 GATA4 was found to be associated with longevity [22279548]. Human
    LYST lysosomal trafficking regulator LYST was found to be associated with longevity [22279548]. Human
    FLJ31951 ring finger protein 145 FLJ31951 was found to be associated with longevity [22279548]. Human
    METAP1 methionyl aminopeptidase 1 METAP1 was found to be associated with longevity [22279548]. Human
    C9orf3 chromosome 9 open reading frame 3 C9orf3 was found to be associated with longevity [22279548]. C9orf3 was found to be associated with longevity [24244950]. Human
    BAT5 abhydrolase domain containing 16A BAT5 was found to be associated with longevity [22279548]. Human
    ACCN1 amiloride-sensitive cation channel 1, neuronal ACCN1 was found to be associated with longevity [22279548]. Human
    FHIT fragile histidine triad gene FHIT was found to be associated with longevity [22279548]. Human
    TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 TNFSF8 was found to be associated with longevity [22279548]. Human
    GBA3 glucosidase, beta, acid 3 (cytosolic) GBA3 was found to be associated with longevity [22279548]. Human
    DOCK8 dedicator of cytokinesis 8 DOCK8 was found to be associated with longevity [22279548]. Human
    ZWINT ZW10 interactor ZWINT was found to be associated with longevity [22279548]. Human
    TOX thymocyte selection-associated high mobility group box TOX was found to be associated with longevity [22279548]. Human
    CGNL1 cingulin-like 1 CGNL1 was found to be associated with longevity [22279548]. Human
    OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) OGDH was found to be associated with longevity [22279548]. Human
    EBF3 early B-cell factor 3 EBF3 was found to be associated with longevity [22279548]. Human
    LMX1B LIM homeobox transcription factor 1, beta LMX1B was found to be associated with longevity [22279548]. Human
    Factors are an extension of GenAge and GenDR.

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