Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    VASH1 vasohibin 1 VASH1 was found to be associated with longevity [22279548]. Human
    CTNNA2 catenin (cadherin-associated protein), alpha 2 CTNNA2 was found to be associated with longevity [22279548]. Human
    KCTD1 potassium channel tetramerisation domain containing 1 KCTD1 was found to be associated with longevity [22279548]. Human
    CAMTA1 calmodulin binding transcription activator 1 CAMTA1 was found to be associated with longevity [22279548]. Human
    PPP2R2B protein phosphatase 2, regulatory subunit B, beta PPP2R2B was found to be associated with longevity [22279548]. Human
    ANGEL1 angel homolog 1 (Drosophila) ANGEL1 was found to be associated with longevity [22279548]. Human
    NAV2 neuron navigator 2 NAV2 was found to be associated with longevity [22279548]. Human
    FLJ20272 tetratricopeptide repeat domain 27 FLJ20272 was found to be associated with longevity [22279548]. Human
    CDK6 cyclin-dependent kinase 6 CDK6 was found to be associated with longevity [22279548]. CDK6 was found to be associated with longevity [24244950]. Human
    RYR3 ryanodine receptor 3 RYR3 was found to be associated with longevity [22279548]. RYR3 was found to be associated with longevity [24244950]. Human
    MEOX2 mesenchyme homeobox 2 MEOX2 was found to be associated with longevity [22279548]. Human
    AIF1 allograft inflammatory factor 1 AIF1 was found to be associated with longevity [22279548]. Human
    OR56A1 olfactory receptor, family 56, subfamily A, member 1 OR56A1 was found to be associated with longevity [22279548]. Human
    LOC285429 DDB1 and CUL4 associated factor 4-like 1 LOC285429 was found to be associated with longevity [22279548]. Human
    DZIP3 DAZ interacting protein 3, zinc finger DZIP3 was found to be associated with longevity [22279548]. Human
    TMEM2 transmembrane protein 2 TMEM2 was found to be associated with longevity [22279548]. Human
    EPB41L4B erythrocyte membrane protein band 4.1 like 4B EPB41L4B was found to be associated with longevity [22279548]. Human
    CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 CHST11 was found to be associated with longevity [22279548]. Human
    TUSC3 tumor suppressor candidate 3 TUSC3 was found to be associated with longevity [22279548]. Human
    DOCK2 dedicator of cytokinesis 2 DOCK2 was found to be associated with longevity [22279548]. Human
    IGSF4 cell adhesion molecule 1 IGSF4 was found to be associated with longevity [22279548]. IGSF4 was not found to be associated with longevity [21612516]. Human
    SOCS2 suppressor of cytokine signaling 2 SOCS2 was found to be associated with longevity [22279548]. Human
    SORCS1 sortilin-related VPS10 domain containing receptor 1 SORCS1 was found to be associated with longevity [22279548]. SORCS1 was not found to be associated with longevity [21612516]. SORCS1 was found to be associated with longevity [24244950]. Human
    HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 HS3ST3B1 was found to be associated with longevity [22279548]. Human
    SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A SEMA6A was found to be associated with longevity [22279548]. Human
    Factors are an extension of GenAge and GenDR.

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