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Symbol: CYR1 Name: CYclic AMP Requirement 1 Alias: HSR1; FIL1; TSM0185; SRA4; CDC35 Entrez gene ID: 853452 Ensembl gene ID: YJL005W Species: Yeast (Taxid: 4932) Functional description: Cyr1p; Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation [Source:SGD;Acc:S000003542] [Ensembl] Observation: The CDC35-1 allele of the adenylate cyclase CYR1 confers a 75% extension of replicative lifespan at 25 degree Celsius [11000115]. Transposon-mutagenized CYR1 increases resistance to oxidants and extends chronological lifespan by up to 90%. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 are required for this lifespan extension [11292860]. CYR1 mutation is assumed to act as genetic DR mimetic [11000115]. The CDC35-1 allele of the adenylate cyclase CYR1 confers a 75% extension of replicative lifespan at 25 degree Celsius [11000115]. cyr1-1 mutation extends median chronological lifespan by 28-47% and is non-addative with lifespan extension conferred by overxpression of human MAPK1 [17662940]. Interventions: Assays: Chronological Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Edit \ Update (Admin) | Delete |
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