|in situ Regeneration ||1 ||2 ||Wuttke; Zamani ||
:Abstract: As we are young everything regenerates perfectly. In fact, our body harbors the plan to reconstruct itself from scratch which is localized in the nucleus of each of our body cells. However, as we grow up our regenerative capacities decre... |
|Tissue-Specific DR-Effects ||2 ||4 ||Kapahi; Magalhaes; Wuttke; Li ||
:Abstract: A restricted diet without malnutrition highly effectively counteracts ageing in several species and extends robustly their lifespan. How lifespan is extended remains enigmatic. We utilized tissue-specific gene expression data in *Droso... |
|Circadian Clock Controls Ageing ||2 ||3 ||Magalhaes; Wuttke; Wood ||
:Abstract: Dietary restriction without malnutrition delays ageing and extends lifespan, but the molecular mechanism is still unknown. Ageing gene expression changes originate from development and growth cessation, are modulated by diet, and manip... |
|Denigma ||5 ||9 ||Fuellen; Magalhaes; Debonneuil; Kulaga; Wuttke; Adams; Borisoglebsky; Fortney; Hall ||Denigma is the digital Enigma destined to decipher biological phenomena. All information of an organism is encoded in its genome and can be decrypted via the combined effort of humans and machines. For this, Denigma was build for.
Specifically, Deni... |
|Circadian Rhythm ||2 ||4 ||Kapahi; Magalhaes; Wuttke; Katewa ||Most animals have rest/activity/rhythms that are powered by an endogenous timing mechanism, the circadian system. With aging the rhythm becomes weaker .
Middle aged flies exhibit reduced activity level in comparison with young controls. ... |
|Pentose Phosphate Pathway ||2 ||3 ||Magalhaes; Wuttke; Tang ||The pentose phosphate pathway chiefly generates reduction equivalents in the form of NADPH:
3 G6P + 6 NADPH+ + 3 H2O = 6 NADPH + 6 H+ + 3 CO2 + 2 F6P + GAP
6 equivalents of NADPH is quite a lot for just three sugars. NADPH might scavenge ROS.
|Gerontology ||2 ||0 || ||The ``Gerontology Ontology`` (the Ontology for Aging and Longevity, ``GERO``) is a mid-level ontology representing aging-related phenomena from the molecular and cellular levels to the social and demographic level. It aims to support gerontological ... |