Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:
ID | name | taxid | reference | pmid | tissue | comparision | start | stop | gender | description |
---|---|---|---|---|---|---|---|---|---|---|
1 | ROS production increases | 4932 | Laun et al., 2001 | 11251834 | — | Age | young | old | — | — |
2 | Downregulation of exo-3 | 6239 | Schlotterer et al., 2010 | 20346071 | Whole body | Age | — | — | — | — |
38 | HDL increases | 9606 | Fontana et al., 2004 | 15096581 | Plasma | Diet | Chronic DR | — | — | — |
41 | Mitochondrial dysfunction increases | 9606 | Petersen et al., 2003 | 12750520 | muscle | Age | — | — | — | Aging is accompanied by an increase in mitochondrial dysfunction in muscle of humans [12750520]. |
50 | Vitamin D3 declines | 9606 | — | — | — | — | — | — | — | As one gets odler te ability for one's skin to create Vitamin D3 declines dramatically. |
51 | DHEA increases | 9606 | Willcox et al., 2007 | 17986602 | serum | diet | Okinawa | — | — | Okinawa aged 65-plus have relatively high DHEA levels. |
59 | Deteriorarition of circadian rhytms | 10090 | Farajnia, et al 2012 | — | Suprachiasmatic Nucleus | age | 2 month | 30 month | — | Aged mice have disrupted sleep hevaiour and weakened brain network activity in the SCN. Aged SCN neurons lack day-night rhythms in some membrane properties. There is an age-related reductions of certain potassium currents that are import to the neuronâs rhythmic firing. Behavioral and sleep-wake rhythms exhibit a strong fragmentation, starting at the age of 700 d. Aged mice are deficient in membrane properties and GABAergic postsynaptic current amplitude. Aging mice selectively loss circadian modulation of fast-delayed-rectifer and A-type K+ currents. In aged mice at the tissue level, the phase synchrony of SCN neurons was grossly disturbed, with some subpopulations peaking in anti-phase and a reduction in amplitude of the overall multiunit activity rhythm. |
65 | Protein expression variation increases | 4932 | Levy et al., 2012 | — | — | age | — | — | — | Transcripts tha become over- or under-expressed in old cells tend to result in protein levels that are more variable across cells in exponential growth [Levy et al., 2012]. |
66 | Tsl1 abundance increases | 4932 | Levy et al., 2012 | — | — | age | — | — | — | Replicative age correlates with a Tsl1-abundant cell state [Levy et al., 2012]. |
68 | Increase in upper and central body fat deposition | 9606 | — | 2921472 | — | age | — | — | — | There are progressive trends toward increasing upper and central body fat deposition with age with a postmenopausal acceleration of these trends in women [2921472]. |
69 | Loss of subcutaneous adipose skin layer | 10090 | — | 19013273 | skin | age | 5 | 165 | — | With increasing age the subcutaneous adipose layer becomes thinner (5-12 weeks vs. 123-165 weeks) and this loss is associated with increased risk of skin injuries and infections [19013273]. |
70 | IGF1 levels decline | 9606 | — | 3322823 | plasma | age | — | — | — | A decline in IGF1 expression occurs with age progression. Levels of circulating IGF1 in humans are low at birth, rise progressively during childhood and peak during midadolescence, and then progressively fall as a function of age. Reduction in levels of circulating IGR1 is related to decreased secretion of growth hormone [3322823]. |
71 | Telomere shortening | 10090 | — | 22585399 | — | age | — | — | — | Average telomere length decreases with age concomitant with an increase in short telomeres [22585399]. Mouse telomeres suffer a dramatic shortening at old ages [18283121;16582880]. |
72 | IGF2 level changes | 9606 | — | 3322823 | plasma | age | — | — | — | Circulating IGF2 reaches âadultâ levels early in childhood, and changes are relatively small as a function of increasing age [3322823]. |
73 | p16 expression increases | 10090 | — | — | — | age | — | — | — | p16 levels increase with aging in many tissues [16957737;16957738] and is a marker of cellular senescence. |
74 | Reduced regenerative capacity | — | — | — | — | — | — | — | — | Aging in mammals is associated with reduced regenerative capacity in tissues that contain stem cells [15734685;11919569]. |
76 | OSH5 upregulation | 4932 | Gebre et al. unpublished | — | — | age | — | — | — | OSH5 level is up-regulated during aging by about 3-15-fold [Gebre et al. unpublished]. |
77 | Osh6 downregulation | — | Gebre et al., unpublished | — | — | age | — | — | — | Total cellular Osh6 levels decrease in aged cells. Osh6 in mid-aged cells is less than half of the Osh6 levels in young cells [Gebre et al., unpublished]. |
78 | Sir2 decline | 4932 | — | 21436897 | — | age | — | — | — | Sir2 levels exhibit an age-related decline at an age of about one thir lifespan expectancies [21436897]. |
79 | Vacuolar membrane deteriorates | 4932 | — | 18690010 | — | age | — | — | — | The vacuolar membrane deteriorates as judged by Vac8 localisation at or before generations 6-7. At generation 6-7, cells begin to exhibit large round vacoules and vacoules with invaginated vacoular membranes [18690010]. |
80 | Cisd2 expression declines | — | — | 22661501 | — | age | — | — | — | Cisd2 expression decreases with age [22661501]. |
81 | elt-5 expression increases | 6239 | 17608836 | 17608836 | — | age | — | — | — | Expression of elt-5 increases with during devleopment and aging [17608836]. |
82 | elt-6 expression increases | 6239 | — | 17608836 | — | age | — | — | — | Expression of elt-6 increases during devleopment and aging [17608836]. |
83 | elt-3 expression increases | 6239 | — | 17608836 | — | age | — | — | — | Expression of elt-3 increases during devleopment and aging [17608836]. |
84 | Cell proliferation increases | 1016 | 11744049 | — | — | Diet | — | — | — | 24 month DR in rats enhances cell proliferation in duodenum and forestomach mucosal tissue [11744049]. |
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