Denigma: Intervention

Cat overexpression

Species: Fruit fly (Taxid: 7227)
Factor: Cat
Manipulation: Gain-of-Function, Overexpression
Effect:

Simultaneous overexpression of catalase and Sod1 results in a one-third (i.e. 30%) lifespan extension, a slower rate of mortality acceleration, and a delayed loss in physical performance, but neither has any effect on lifespan alone [8108730]. Targeted overexpression of CAT in the mitochondrial matrix has no effect on lifespan at 25 degree Celsius, slightly shortens lifespan at 29 degree Celsius as is associated with increased resistance to endogenous hydrogen peroxide, paraquat, and cold stress [12521602].

References:

8108730: Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

12521602: Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity.

Aging Relevance Analysis/Source:

GenAge