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Symbol: gcy-28 Name: Guanylyl CYclase Entrez gene ID: 172051 Ensembl gene ID: T01A4.1 Species: Worm (Taxid: 6239) Functional description: Natriuretic peptide receptor, guanylate cyclase; Protein GCY-28; Guanylyl CYclase family member (gcy-28) [Source:RefSeq peptide;Acc:NP_001021600] [Ensembl]; gcy-28 encodes a membrane-bound guanylyl cyclase with an extracellular ligand binding domain, a transmembrane domain, and a guanylyl cyclase domain; GCY-28 regulates odor preferences in AWC sensory neurons; gcy-28 regulates the sensory integration in the nervous system and that function of gcy-28 at adulthood is sufficient for normal sensory integration; GCY-28 in AIA interneurons is important for sensory integration; gcy-28 and cng-1 operate in the same genetic pathway to regulate sensory integration; GCY-28 and SCD-2 function in distinct pathways; gcy-28.c isoform is expressed in many neurons and gcy-28.d isoform is expressed specifically in a pair of interneurons, AIA. [WormBase] Observation: RNA interference extended lifespan. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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