Denigma

14-3-3epsilon

Symbol: 14-3-3epsilon
Name: CG31196 gene product from transcript CG31196-RA
Entrez gene ID: 42186
Ensembl gene ID: FBgn0020238
Species: Fly (Taxid: 7227)


Observation:

Loss of 14-3-3ε results in increased stress-induced apoptosis, growth repression and extended lifespan of flies, in a foxo-dependent manner. Mean lifespan of males and females is increased by 25% and 49%, respectively. Increased 14-3-3ε expression also reverts foxo-induced growth defects. No effect of lifespan is observed when overexpressing 14-3-3ε in adipose tissue, indicating that endogenous foxo activity in this tissue is low under normal conditions [18665908].



Assays: Organismal Lifespan
Mean: +25 to +49

Classification:
  • Gerontogene
  • Positive Gerontogene


    • Type:
  • Gene
  • Protein coding

    References:
  • 18665908: 14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • YWHAE (9606)
  • YWHAE (9598)
  • YWHAE (9615)
  • YWHAE (9913)
  • Ywhae (10090)
  • Ywhae (10116)
  • YWHAE (9031)
  • ywhae1 (7955)
  • 14-3-3epsilon (7227)
  • AgaP_AGAP001151 (7165)
  • rad24 (4896)
  • GeneID:5049025 (148305)
  • GRF7 (3702)
  • GRF5 (3702)
  • GRF3 (3702)
  • Os04g0462500 (4530)
  • Os02g0580300 (4530)
  • Os08g0430500 (4530)
  • Os03g0710800 (4530)

    • Orthologs
  • BMH1 (4932)
  • BMH2 (4932)
  • BMH1 (4932)
  • BMH2 (4932)

    • Inparanoids
  • ENSMUSP00000070993 (10090)
  • ENSRNOP00000007100 (10116)
  • ENSP00000264335 (9606)
  • YER177W (4932)
  • SPAC8E11.02c (4896)



    • Edit \ Update (Admin) | Delete

    Comment on This Data Unit