Symbol: ucp-4 Name: UnCoupling Protein (mitochondrial substrate carrier) family member (ucp-4) Entrez gene ID: 179315 Ensembl gene ID: K07B1.3 Species: Worm (Taxid: 6239) Functional description: Protein UCP-4; UnCoupling Protein (mitochondrial substrate carrier) family member (ucp-4) [Source:RefSeq peptide;Acc:NP_505414] [Ensembl]; ucp-4 encodes an uncoupling protein related to mammalian mitochondrial uncoupling protein 4 (UCP4) also known as solute carrier family 25, member 27 (SLC25A27); UCP-4 is predicted to function to uncouple ATP production from electron transport and, consistent with this, ucp-4 mutant animals contain elevated ATP levels; ucp-4 activity is also required for normal rates of survival in response to cold treatment; a ucp-4::gfp promoter fusion is expressed in head and body wall muscles and in the pharynx. [WormBase] Observation: Overexpression reduces mean lifespan by 5%, has no significant effect on median lifespan, and slighlty increases maximum lifespan by 12% [22737090]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Note: It has some effect on maximum lifespan though. Edit \ Update (Admin) | Delete |
Comment on This Data Unit