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Symbol: cel-1 Name: mRNA Capping Enzyme Like 1 Entrez gene ID: 172814 Ensembl gene ID: C03D6.3 Species: Worm (Taxid: 6239) Functional description: Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. [UniProt] Observation: RNA interference of cel-1 decreases median lifespan 76% in daf-2 mutants, 15% in daf-2/daf-16 double mutants, and 59% wild-type animals [18006689]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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