Authors: Kim EJ; Kim MK; Jin XJ; Oh JH; Kim JE; Chung JH
Abstract: We investigated the alterations of major fatty acid components in epidermis by natural aging and photoaging processes, and by acute ultraviolet (UV) irradiation in human skin. Interestingly, we found that 11,14,17-eicosatrienoic acid (ETA), which is one of the omega-3 polyunsaturated acids, was significantly increased in photoaged human epidermis in vivo and also in the acutely UV-irradiated human skin in vivo, while it was significantly decreased in intrinsically aged human epidermis. The increased ETA content in the epidermis of photoaged human skin and acute UV-irradiated human skin is associated with enhanced expression of human elongase 1 and calcium-independent phosphodiesterase A(2). We demonstrated that ETA inhibited matrix metalloproteinase (MMP)-1 expression after UV-irradiation, and that inhibition of ETA synthesis using EPTC and NA-TCA, which are elongase inhibitors, increased MMP-1 expression. Therefore, our results suggest that the UV increases the ETA levels, which may have a photoprotective effect in the human skin.
Keywords: 8,11,14-Eicosatrienoic Acid/chemistry/*metabolism; Acetyltransferases/antagonists & inhibitors/metabolism; Adult; Aged; Cell Line; Epidermis/*metabolism/radiation effects; Fatty Acids/chemistry/*metabolism; Humans; Keratinocytes/metabolism; Matrix Metalloproteinase 1/metabolism; Phospholipases A2, Calcium-Independent/metabolism; *Skin Aging; Thiocarbamates/pharmacology; *Ultraviolet Rays; Young Adult
Journal: Journal of Korean medical science Volume: 25 Issue: 6 Pages: 980-3 Date: June 2, 2010 PMID: 20514327 |
Kim EJ, Kim MK, Jin XJ, Oh JH, Kim JE, Chung JH (2010) Skin aging and photoaging alter fatty acids composition, including 11,14,17-eicosatrienoic acid, in the epidermis of human skin. Journal of Korean medical science 25: 980-3.
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