Polymorphism: many SNPs
Location: 11p15.5
Factor:
- Symbol: SIRT3
- Name: sirtuin 3
- Entrez ID: 23410
- Ensembl ID: ENSG00000142082
Factors:
SIRT3
sirtuin 3
(
23410
/
ENSG00000142082
)
Description:
For the replication study, "eight SNPs were tested in a French sample (...mean [age] 51.2)... None of the earlier findings were confirmed in this analysis."
Ethnicity:
Italian
Age of cases: Mean age 101.9 (southern Italian) | Mean age 101.0 (northern-central Italian) | Mean age 104.41 (German)
Statistics
- Number of cases/controls: 92 vs 97 (southern Italian) | 307 vs 352 (nothern-central Italian) | 376 vs 376 (German) (initial)
| 546 vs 315 (replication)
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: SNPlex technology (Applied Biosystems)
Reference:
19367319: Human longevity and 11p15.5: a study in 1321 centenarians.
Choice: Curate
Created: July 1, 2013, 1:03 p.m.
Updated: Aug. 26, 2013, 1:25 p.m.
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