Polymorphism: (rs429358, rs7412) + (rs2075650)
(rs429358,
(
SNPedia |
23andMe
)
rs7412)
(
SNPedia |
23andMe
)
(rs2075650)
(
SNPedia |
23andMe
)
Factor:
- Symbol: APOE + TOMM40
Factors:
APOE + TOMM40
Description:
Not significant because the linkage disequilibrium was weak.
Ethnicity:
Dutch
Age of cases: Mean age 94
Shorter lived allele: e4 + G
Finding: Negative
Statistics
- Number of cases/controls: 403 vs 1670 (initial)
| 3746 vs 5912 (replication)
- Odds ratio: 0.93
- p-value:
0.337
[0.337]
- Significant: No
Study Design
- Classifications:
No Age Effect
- Study type: Genome-Wide Association Study
- Technology: Illumina Infinium HD Human660W-Quad BeadChips; Illumina Infinium II HumanHap550-Duo BeadChips
Reference:
21418511: Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Choice: Curate
Created: July 2, 2013, 2:54 a.m.
Updated: Aug. 8, 2014, 1:05 p.m.
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