Denigma Buck Institute Health Extension
Polymorphism: rs429358, rs7412
rs429358, ( SNPedia | 23andMe )
rs7412 ( SNPedia | 23andMe )

Location: 19q13.2

Factor:
- Symbol: APOE
- Name: apolipoprotein E
- Entrez ID: 348
- Ensembl ID: ENSG00000130203

Factors:
  • APOE apolipoprotein E ( 348 / ENSG00000130203 )


    • Description:

    odds_ratio = 0.62 (1.31) (invalid literal for float(): 0.62 (1.31))

    pvalue = 1.33x10^-23 (1.35x10^-6) (invalid literal for float(): 1.33E-23(1.35E-6))

    Ethnicity: Dutch
    Age of cases: Mean age 94
    Shorter lived allele: e4
    Longer lived allele: e2

    Statistics
    - Number of cases/controls: 403 vs 1670 (initial) | 3746 vs 5912 (replication)
    - p-value: [1.33x10^-23 (1.35x10^-6)]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Genome-Wide Association Study
    - Technology: Illumina Infinium HD Human660W-Quad BeadChips; Illumina Infinium II HumanHap550-Duo BeadChips

    Reference:
    21418511: Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.

    Choice: Curate
    Created: July 2, 2013, 2:54 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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