Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):


  • Variant type: + -

  • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
    Export results (Download)

    Populations | Study Types | Variant Types



    LVDB_word_cloud.png
    logo.png
    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs2251101 IDE 1.88 0.0011 829 vs 1033 Australian, Caucasian Mixed Candidate Region/Gene 18448515
    55 (L/M) PON1 0.94 0.44 308 vs 579 Italian, 296 vs 296 Irish Irish, Italian Italian 100.8 years, Irish 89.8 years Candidate Region/Gene 15050299
    rs12770830 HSPA14 1.35 0.011 1,089 vs 736 1,613 vs 1,104 Danish, German 92-93 Danish, 95–110 German 22234866
    rs1685354 UCP3 0.762 908 vs 708 Danish 93 Candidate Region/Gene 22743239
    rs647126 UCP3 0.447 908 vs 708 Danish 93 Candidate Region/Gene 22743239
    SV-6 CLU 1.0 49 vs 27 vs 20 Greek, Italian 99–107 Candidate Region/Gene 16804001
    rs1800629 TNF 1.0 119 vs 118 Jordanian Mean age 90.2 Candidate Region/Gene 20518833
    rs1043618 HSP70-A1A 1.0 347 vs 238 American, Ashkenazi Jewish Minimum age 100 Candidate Region/Gene 17027907
    rs6457452 HSP70-A1B 1.0 347 vs 238 American, Ashkenazi Jewish Minimum age 100 Candidate Region/Gene 17027907
    rs708272 CETP 1.0 12 vs 190 vs 105 Greek 99-111 Candidate Region/Gene 23389097
    rs5882 CETP 1.0 12 vs 190 vs 105 Greek 99-111 Candidate Region/Gene 23389097
    H63D HFE 1.0 35 vs 106 91-105 Candidate Region/Gene 11857056
    S65C HFE 1.0 35 vs 106 91-105 Candidate Region/Gene 11857056
    - Insulin signaling pathway (IIS) 0.01 403 vs 1670 European 90-103 Genome-Wide Association Study 22113349
    - Telomere maintenance pathway (TM) 0.02 403 vs 1670 European 90-103 Genome-Wide Association Study 22113349
    rs3758391 SIRT1 1.0 386 vs 640 vs 547 German Mean age 101 Candidate Region/Gene 16257164
    rs1885472 SIRT1 1.0 386 vs 640 vs 547 German Mean age 101 Candidate Region/Gene 16257164
    rs2273773 SIRT1 1.0 386 vs 640 vs 547 German Mean age 101 Candidate Region/Gene 16257164
    rs10997870 SIRT1 1.0 386 vs 640 vs 547 German Mean age 101 Candidate Region/Gene 16257164
    rs2234975 SIRT1 1.0 386 vs 640 vs 547 German Mean age 101 Candidate Region/Gene 16257164
    rs1801274 FCGR2A 1.0 408 vs 446 vs 454 German Centenarians Candidate Region/Gene 16893392
    3p24-22 3p24-22 0.037 3953 American Minimum age 98 Genome-Wide Association Study 20824210
    C150T mtDNA L2 1.0 556 vs. 403 Chinese 90-108 Mitochondrial Haplogroup 21262335
    rs854560 PON1 1.0 579 vs 308 Italian Over 100 Candidate Region/Gene 12082503
    192/55 loci PON1 0.01 579 vs 308 Italian Over 100 R+M+ Candidate Region/Gene 12082503
    • Page 1 of 66
    • 25 of 1635 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


    Suggest a new study Report a database issue