Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):


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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    mtDNA haplotype 0.0052 212 vs 275 Italian 100+ non-J haplogroups Mitochondrial Haplogroup 10463944
    55 (L/M) PON1 0.94 0.44 308 vs 579 Italian, 296 vs 296 Irish Irish, Italian Italian 100.8 years, Irish 89.8 years Candidate Region/Gene 15050299
    192 (Q/R) PON1 1.30 0.007 308 vs 579 Italian, 296 vs 296 Irish Irish, Italian Italian 100.8 years, Irish 89.8 years Q Candidate Region/Gene 15050299
    apoE haplotypes 0.02 80 vs 391 Greek 80+ Apo e4 Candidate Region/Gene 17234815
    ?60H LMP2 0.756 157 vs 311 Italian 88+ H Candidate Region/Gene 11772516
    ?145K LMP7 0.849 157 vs 311 Italian 88+ K Candidate Region/Gene 11772516
    apoE haplotypes 0.0042 3924 American 5-70 Apo e4 Candidate Region/Gene 21332925
    rs11235972 UCP3 0.029 908 vs 708 Danish 93 A Candidate Region/Gene 22743239
    rs1685354 UCP3 0.762 908 vs 708 Danish 93 Candidate Region/Gene 22743239
    rs3781907 UCP3 0.05 908 vs 708 Danish 93 G Candidate Region/Gene 22743239
    rs647126 UCP3 0.447 908 vs 708 Danish 93 Candidate Region/Gene 22743239
    82133 G>A 0.0189 33 vs 39 Japanese 90+ A Candidate Region/Gene 15820493
    APOE e2/e3/e4 APOE 4.40 0.02 179 Finn Minimum age 104 e3, e4 e2 Candidate Region/Gene 11213279
    G/A-IGF1R, Gly/Asp-IRS2, and Ala/Val-UCP2 allele combination 3.19 0.0006 208 vs 514 Italian Mean age 96 non-AAV allele combi AAV allele combinati Candidate Region/Gene 21340542
    rs2802288 FOXO3A 1.51 0.003 281 vs 195 Italian 90–108 G A Candidate Region/Gene 19415983
    rs1800629 TNF 1.0 119 vs 118 Jordanian Mean age 90.2 Candidate Region/Gene 20518833
    rs1800896 IL10 0.031 119 vs 118 Jordanian Mean age 90.2 G A Candidate Region/Gene 20518833
    G1691A F5 0.004 432 vs 184 Polish Minimum age 95 A G Candidate Region/Gene 20720309
    rs1799752 ACE 0.016 12 vs 190 vs 105 Greek 99-111 D I Candidate Region/Gene 23389097
    rs708272 CETP 1.0 12 vs 190 vs 105 Greek 99-111 Candidate Region/Gene 23389097
    rs5882 CETP 1.0 12 vs 190 vs 105 Greek 99-111 Candidate Region/Gene 23389097
    H63D HFE 1.0 35 vs 106 91-105 Candidate Region/Gene 11857056
    S65C HFE 1.0 35 vs 106 91-105 Candidate Region/Gene 11857056
    - Insulin signaling pathway (IIS) 0.01 403 vs 1670 European 90-103 Genome-Wide Association Study 22113349
    - Telomere maintenance pathway (TM) 0.02 403 vs 1670 European 90-103 Genome-Wide Association Study 22113349
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    • 25 of 1635 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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