The major locus determining familial longevity up to high age as detected by GWAS is marked by rs2075650, which tags the deleterious effects of the ApoE epsilon4 allele [21418511].
Ethnicity:Dutch Age of cases: mean 94 Shorter lived allele: e4 Finding: Positive
Statistics - Number of cases/controls: 403 vs 1670 (initial)
| 4149 vs 7582 (replication) - Odds ratio: 0.71 - p-value:
3.39e-17
[3.39e-17]
- Significant: yes
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