Denigma

Spargel overexpression

Species: Fruit fly (Taxid: 7227)
Factor: Spargel
Manipulation: Gain-of-Function, Overexpression
Effect:

Tissue-specific overexpression of dPGC-1 in stem and progenitor cells within the digestive tract of females flies extends the median and maximum lifespan of females by up to 33% and 37%. Those mutants display a delay in the onset of aging-related changes in the intestine, leading to improved tissue homoeostasis in old flies [22055505].

Median: +33
Maximum: +37

References:
  • 22055505: Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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