High-quality life extension by the enzyme peptide methionine sulfoxide reductase.

Authors: Ruan H; Tang XD; Chen ML; Joiner ML; Sun G; Brot N; Weissbach H; Heinemann SH; Iverson L; Wu CF; Hoshi T

Abstract: Cumulative oxidative damages to cell constituents are considered to contribute to aging and age-related diseases. The enzyme peptide methionine sulfoxide reductase A (MSRA) catalyzes the repair of oxidized methionine in proteins by reducing methionine sulfoxide back to methionine. However, whether MSRA plays a role in the aging process is poorly understood. Here we report that overexpression of the msrA gene predominantly in the nervous system markedly extends the lifespan of the fruit fly Drosophila. The MSRA transgenic animals are more resistant to paraquat-induced oxidative stress, and the onset of senescence-induced decline in the general activity level and reproductive capacity is delayed markedly. The results suggest that oxidative damage is an important determinant of lifespan, and MSRA may be important in increasing the lifespan in other organisms including humans.

Keywords: Animals; Animals, Genetically Modified; Drosophila melanogaster/genetics/physiology; *Longevity/physiology; Methionine Sulfoxide Reductases; Oxidoreductases/genetics/*physiology; Peptides
Journal: Proceedings of the National Academy of Sciences of the United States of America
Volume: 99
Issue: 5
Pages: 2748-53
Date: Feb. 28, 2002
PMID: 11867705
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Citation:

Ruan H, Tang XD, Chen ML, Joiner ML, Sun G, Brot N, Weissbach H, Heinemann SH, Iverson L, Wu CF, Hoshi T (2002) High-quality life extension by the enzyme peptide methionine sulfoxide reductase. Proceedings of the National Academy of Sciences of the United States of America 99: 2748-53.


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