Authors: Jylhävä J; Eklund C; Jylhä M; Hervonen A; Lehtimäki T; Karhunen P; Hurme M
Abstract: Ageing is characterized by chronic low-grade inflammation and the expected lifespan may be affected by several immunological and inflammatory mediators. In this study, we investigated whether the functional Tyr402His polymorphism (rs1061170) on complement factor H (CFH) gene, which is a key inflammatory downregulator, modulates the longevity of 491 nonagenarians in the Vitality 90+ study. Logistic regression analysis and Kaplan-Meier method with the log rank test were used to examine the effect of the CFH Tyr402His polymorphism on 4-year mortality. After follow-up, we observed that risk factor-adjusted mortality was significantly higher among the carriers of CFH 402His allele compared to non-carriers (OR 1.78, 95% CI 1.19-2.67, p=0.005) and that the survival curves of CFH 402His carriers and non-carriers deviated significantly (p=0.016). We propose that the increased mortality is inflammation-related and mediated by aberrant complement regulation by the CFH 402His variant.
Keywords: Aged, 80 and over; Aging/*genetics/physiology; Complement Factor H/*genetics; Female; Genetic Variation; Humans; Inflammation Mediators/*blood; Longevity; Male; Polymorphism, Genetic|
Journal: Experimental gerontology Volume: 44 Issue: 4 Pages: 297-9 Date: Nov. 13, 2008 PMID: 19000922 |
Jylhävä J, Eklund C, Jylhä M, Hervonen A, Lehtimäki T, Karhunen P, Hurme M (2009) Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study. Experimental gerontology 44: 297-9.
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