Heat-shock protein 70 genes and human longevity: a view from Denmark.

Authors: Singh R; Kølvraa S; Bross P; Christensen K; Gregersen N; Tan Q; Jensen UB; Eiberg H; Rattan SI

Abstract: We have studied the association of three single nucleotide polymorphisms (SNPs) present in the three HSP70 (heat-shock protein) genes on 6p21 with human longevity. The availability of biological samples from various population cohorts in Denmark has given us the opportunity to try novel methods of gene association with human longevity. A significant association of one haplotype with male longevity was observed. Furthermore, a significant difference in the survival of the carriers of the different genotypes in females was observed. We also found an age-dependant decline in the ability of peripheral blood mononuclear cells to respond to heat stress in terms of Hsp70 induction.

Keywords: Adult; Aged; Aged, 80 and over; Chromosomes, Human, Pair 6; Cohort Studies; Denmark; Female; Gene Frequency; HSP70 Heat-Shock Proteins/blood/genetics/*metabolism; Haplotypes; Heat-Shock Response/genetics/*physiology; Heterozygote; Humans; Linkage Disequilibrium; Longevity/genetics/*physiology; Male; Nuclear Family; Polymorphism, Single Nucleotide; Survival Analysis; Twins/*genetics
Journal: Annals of the New York Academy of Sciences
Volume: 1067
Pages: 301-8
Date: June 29, 2006
PMID: 16804002
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Citation:

Singh R, Kølvraa S, Bross P, Christensen K, Gregersen N, Tan Q, Jensen UB, Eiberg H, Rattan SI (2006) Heat-shock protein 70 genes and human longevity: a view from Denmark. Annals of the New York Academy of Sciences 1067: 301-8.


Lifespan Factors:
  • HSPA1B heat shock 70kDa protein 1A

  • Longevity Variant Associations (p-value):
  • rs1008438 (0.005)
  • rs1061581 (0.04)
  • rs2227956
  • rs1008438 (0.005)
  • rs1061581 (0.04)

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