Neuroprotective and anti-ageing effects of curcumin in aged rat brain regions.

Authors: Bala, Kiran; Tripathy, B C; Sharma, Deepak

Abstract: This study investigated the influence of chronically administered curcumin on normal ageing-related parameters: lipid peroxidation, lipofuscin concentration and intraneuronal lipofuscin accumulation, activities of the enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx), and Na(+), K(+), -adenosine triphosphatase (Na(+), K(+), -ATPase) in different brain regions (cerebral cortex, hippocampus, cerebellum and medulla) of 6- and 24-month-old rats. In normal ageing, lipid peroxidation and lipofuscin concentration were found to increase with ageing, the activities of SOD, GPx and Na(+), K(+), -ATPase, however, decreased with ageing. Chronic curcumin treatment of both 6 and 24 months old rats resulted in significant decreases in lipid peroxide and the lipofuscin contents in brain regions, the activities of SOD, GPx and Na(+), K(+), -ATPase however, showed significant increase in various brain regions. The present study, thus, demonstrated the antioxidative, antilipofusinogenesic and anti-ageing effects of curcumin in the brain.

Keywords: Aging/*drug effects/metabolism; Animals; Brain/*drug effects/metabolism; Cerebellum/drug effects/metabolism; Curcumin/*pharmacology; Enzyme Inhibitors/*pharmacology; Glutathione Peroxidase/metabolism; Hippocampus/drug effects/metabolism; Lipid Peroxidation/drug effects; Lipofuscin/metabolism; Male; Medulla Oblongata/drug effects/metabolism; Neuroprotective Agents/*pharmacology; Parietal Lobe/drug effects/metabolism; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase/metabolism; Superoxide Dismutase/metabolism
Journal: Biogerontology
Volume: 7
Issue: 2
Pages: 81-9
Date: April 1, 2006
PMID: 16802111
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Categories: Aging
Citation:

Bala, Kiran, Tripathy, B C, Sharma, Deepak (2006) Neuroprotective and anti-ageing effects of curcumin in aged rat brain regions. Biogerontology 7: 81-9.



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