Modular organization of cellular networks.

Authors: Rives AW; Galitski T

Abstract: We investigated the organization of interacting proteins and protein complexes into networks of modules. A network-clustering method was developed to identify modules. This method of network-structure determination was validated by clustering known signaling-protein modules and by identifying module rudiments in exclusively high-throughput protein-interaction data with high error frequencies and low coverage. The signaling network controlling the yeast developmental transition to a filamentous form was clustered. Abstraction of a modular network-structure model identified module-organizer proteins and module-connector proteins. The functions of these proteins suggest that they are important for module function and intermodule communication.

Keywords: *Cell Communication; Cluster Analysis; Databases as Topic; Fungal Proteins/*metabolism; *Signal Transduction; Software
Journal: Proceedings of the National Academy of Sciences of the United States of America
Volume: 100
Issue: 3
Pages: 1128-33
Date: Jan. 23, 2003
PMID: 12538875
Select reference article to upload


Notes:

Network



Citation:

Rives AW, Galitski T (2003) Modular organization of cellular networks. Proceedings of the National Academy of Sciences of the United States of America 100: 1128-33.



Update (Admin) | Auto-Update

Comment on This Data Unit