Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy.

Authors: Waskar M; Landis GN; Shen J; Curtis C; Tozer K; Abdueva D; Skvortsov D; Tavaré S; Tower J

Abstract: Truncated and mutant forms ofp53 affect life span in Drosophila, nematodes and mice, however the role of wild-type p53 in aging remains unclear. Here conditional over-expression of both wild-type and mutant p53 transgenes indicated that, in adult flies, p53 limits life span in females but favors life span in males. In contrast, during larval development, moderate over-expression of p53 produced both male and female adults with increased life span. Mutations of the endogenous p53 gene also had sex-specific effects on life span under control and stress conditions: null mutation of p53 increased life span in females, and had smaller, more variable effects in males. These developmental stage-specific and sex-specific effects of p53 on adult life span are consistent with a sexual antagonistic pleiotropy model.

Keywords: Aging/genetics/*physiology; Animals; Drosophila Proteins/genetics/*physiology; Drosophila melanogaster/genetics/growth & development/*physiology; Female; Gene Transfer Techniques; Genotype; Larva/genetics/growth & development/physiology; Longevity/genetics/*physiology; Male; Models, Animal; Models, Biological; Mutation/genetics; *Phenotype; *Sex Characteristics; Tumor Suppressor Protein p53/genetics/*physiology
Journal: Aging
Volume: 1
Issue: 11
Pages: 903-36
Date: Feb. 17, 2010
PMID: 20157574
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Citation:

Waskar M, Landis GN, Shen J, Curtis C, Tozer K, Abdueva D, Skvortsov D, Tavaré S, Tower J (2009) Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy. Aging 1: 903-36.


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