Lifespan extending activity of substances secreted by the nematode Caenorhabditis elegans that include the dauer-inducing pheromone.

Authors: Kawano T; Kataoka N; Abe S; Ohtani M; Honda Y; Honda S; Kimura Y

Abstract: The nematode Caenorhabditis elegans yields a substance(s) inducing the larval diapause, called dauer-inducing pheromone. We discovered that the crude pheromone extract extends the adult lifespan in the animal. This extension does not occur in the mutant animal, in which expansion of the lifespan caused by other mutations reducing insulin signaling is suppressed. This is the first description concerning the relevancy of the pheromone to the longevity in the animal.

Keywords: Aging/drug effects/physiology; Animals; Antimetabolites/pharmacology; Caenorhabditis elegans/drug effects/*growth & development; Caenorhabditis elegans Proteins/*pharmacology; Floxuridine/pharmacology; Insulin/physiology; Larva; Longevity/*drug effects; Mutation/genetics; Pheromones/*pharmacology; Signal Transduction/drug effects

Journal: Bioscience, biotechnology, and biochemistry Volume: 69 Issue: 12 Pages: 2479-81 Date: Dec. 27, 2005 PMID: 16377915

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Citation:

Kawano T, Kataoka N, Abe S, Ohtani M, Honda Y, Honda S, Kimura Y (2005) Lifespan extending activity of substances secreted by the nematode Caenorhabditis elegans that include the dauer-inducing pheromone. Bioscience, biotechnology, and biochemistry 69: 2479-81.

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