A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans.

Authors: Morris JZ; Tissenbaum HA; Ruvkun G

Abstract: A pheromone-induced neurosecretory pathway in Caenorhabditis elegans triggers developmental arrest and an increase in longevity at the dauer diapause stage. The gene age-1 is required for non-dauer development and normal senescence. age-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase (PI(3)K) catalytic subunits. Lack of both maternal and zygotic age-1 activity causes dauer formation, whereas animals with maternal but not zygotic age-1 activity develop as non-dauers that live more than twice as long as normal. These data suggest that phosphatidylinositol signalling mediated by AGE-1 protein controls lifespan and the dauer diapause decision.

Keywords: Amino Acid Sequence; Animals; Caenorhabditis elegans/*enzymology/genetics/physiology; *Caenorhabditis elegans Proteins; Chromosome Mapping; Helminth Proteins/genetics/*physiology; Longevity/*physiology; Molecular Sequence Data; Mutation; Phosphatidylinositol 3-Kinases; Phosphatidylinositols/metabolism; Phosphotransferases (Alcohol Group Acceptor)/genetics/*physiology; Signal Transduction
Journal: Nature
Volume: 382
Issue: 6591
Pages: 536-9
Date: Aug. 8, 1996
PMID: 8700226
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Citation:

Morris JZ, Tissenbaum HA, Ruvkun G (1996) A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382: 536-9.


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