Authors: Hars, Eszter S; Qi, Haiyan; Ryazanov, Alexey G; Jin, Shengkan; Cai, Li; Hu, Chengcheng; Liu, Leroy F
Abstract: The role of autophagy in ageing regulation has been suggested based on studies in C. elegans, in which knockdown of the expression of bec-1 (ortholog of the yeast and mammalian autophagy genes ATG6/VPS30 and beclin 1, respectively) shortens lifespan of the daf-2(e1370) mutant C. elegans. However, Beclin1/ATG6 is also known to be involved in other cellular functions in addition to autophagy. In the current study, we knocked down two other autophagy genes, atg-7 and atg-12, in C. elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation.
Keywords: Aging/*physiology; Animals; Autophagy/*physiology; Caenorhabditis elegans/*physiology; Caenorhabditis elegans Proteins/genetics/metabolism; Longevity/*physiology; Proportional Hazards Models; RNA Interference; Survival Analysis
Journal: Autophagy Volume: 3 Issue: 2 Pages: 93-5 Date: Jan. 6, 2007 PMID: 17204841 |
Hars, Eszter S, Qi, Haiyan, Ryazanov, Alexey G, Jin, Shengkan, Cai, Li, Hu, Chengcheng, Liu, Leroy F (2007) Autophagy regulates ageing in C. elegans. Autophagy 3: 93-5.
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