14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans.

Authors: Araiz C; Château MT; Galas S

Abstract: Caenorhabditis elegans life span, stress resistance and metabolism are regulated by the Insulin/IGF-1/DAF-2/DAF-16 pathway. DAF-16, a member of FOXO/Forkhead transcription factor family, can be targeted by 14-3-3 proteins to promote stress resistance. We have identified a 14-3-3 C. elegans homolog which promotes life span by both DAF-2-dependent and -independent mechanisms and by an unexpected DAF-16-independent mechanism. Our results demonstrate that C. elegans 14-3-3 proteins modulate stress-responsive genes throughout adulthood. In conclusion, 14-3-3 can be considered as an acute stress-responsive regulator as well as a sustained modulator of the Insulin/IGF-1/DAF-2/DAF-16 regulatory pathway in promoting life expectancy of growing old worms.

Keywords: 14-3-3 Proteins/genetics/*physiology; Aging/physiology; Animals; Bacteria/genetics; Caenorhabditis elegans/*physiology; Caenorhabditis elegans Proteins/genetics/*metabolism; *Gene Expression Regulation, Developmental; Genes, Helminth; Insulin/metabolism; Insulin-Like Growth Factor I/metabolism; Longevity/*physiology; Oxidative Stress; RNA Interference; RNA, Small Interfering/pharmacology; Receptor, Insulin/genetics/*metabolism; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors/genetics/*metabolism; Transgenes
Journal: Experimental gerontology
Volume: 43
Issue: 6
Pages: 505-19
Date: April 22, 2008
PMID: 18423931
Select reference article to upload


Citation:

Araiz C, Château MT, Galas S (2008) 14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans. Experimental gerontology 43: 505-19.


Study
Update (Admin) | Auto-Update

Comment on This Data Unit