Epigentic changes are a general feature of the iPSC state and are independent of somatic cell source. The reprogramming efficiency inversley correlates with the amount of methylation changes needed to acquiere pluripotency. Analysis of different iPSC lines from muliple cell types of origin revealed a molecular reprogramming-specific epigenetic signature consisting of nine abberrant methylated genes that segregate ESC and iPSC lines regardless of the somtic cell source or differentiation state.
Science-News/121391-Discovery-Of-Reprogramming-Signature-May-Help-Further-Stem-Cell-Based-Regenerative-Medicine-Research/">Discovery Of Reprogramming Signature May Help Further Stem Cell-Based Regenerative Medicine Research
Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells
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