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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs4986790 TLR4 0.61 273 vs 594 German Mean age 97.9 Candidate Region/Gene 17493663
rs2590504 KIAA0649 0.00854 1173 vs 570 American 85-100 C Genome-Wide Association Study 22533364
rs1048310 0.87 208 vs 399 Japanese 95+ Candidate Region/Gene 23770741
rs2024714 CDH4 7.43e-05 1173 vs 570 American 85-100 C Genome-Wide Association Study 22533364
rs4731030 Intergenic 0.90 4.37e-05 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American A Genome-Wide Association Study 21782286
rs6519194 ATF4 0.41 206 vs 397 Japanese 95+ Candidate Region/Gene 23770741
rs41383 NLRC5 0.00455 1173 vs 570 American 85-100 C Genome-Wide Association Study 22533364
rs310020 Intergenic 0.93 4.45e-05 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American A Genome-Wide Association Study 21782286
rs738288 ATF4 0.54 205 vs 396 Japanese 95+ Candidate Region/Gene 23770741
rs16975963 Noncoding 0.00713 1173 vs 570 American 85-100 G Genome-Wide Association Study 22533364
rs6589722 0.015 209 vs 402 Japanese 95+ Candidate Region/Gene 23770741
rs13008689 Intergenic 0.00686 1173 vs 570 American 85-100 A Genome-Wide Association Study 22533364
rs7705041 Intergenic 0.83 4.62e-05 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American A Genome-Wide Association Study 21782286
rs12786104 CBL 0.12 210 vs 398 Japanese 95+ Candidate Region/Gene 23770741
- TH 0.045 202 vs 170 vs 82 Italian 100-105 (oldest of 3 age groups, see notes) Candidate Region/Gene 11053670
rs3120819 Intergenic 0.00806 1173 vs 570 American 85-100 C Genome-Wide Association Study 22533364
rs2244300 Intergenic 0.93 4.73e-05 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American A Genome-Wide Association Study 21782286
rs11217184 CBL 0.8 212 vs 396 Japanese 95+ Candidate Region/Gene 23770741
SV-6 CLU 1.0 49 vs 27 vs 20 Greek, Italian 99–107 Candidate Region/Gene 16804001
I/D (insertion/deletion) ACE 0.33 560 vs 560 French centenarians 100th year or beyond, mean age 103.1 Candidate Region/Gene 11280044
rs9876781 Noncoding 0.000868 1173 vs 570 American 85-100 A Genome-Wide Association Study 22533364
rs2249466 CBL 0.9 207 vs 394 Japanese 95+ Candidate Region/Gene 23770741
rs9517320 STK24 0.00204 1173 vs 570 American 85-100 C Genome-Wide Association Study 22533364
rs7914 CBL 0.69 190 vs 376 Japanese 95+ Candidate Region/Gene 23770741
rs139170 PARVG 0.00332 1173 vs 570 American 85-100 T Genome-Wide Association Study 22533364
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  • 25 of 1635 variants