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Longevity DB
Genetic variants implicated in human longevity.
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polymorphism
factor
odds ratio
pvalue
initial number
replication number
Population
age of cases
shorter lived allele
longer lived allele
study type
reference
rs4986790
TLR4
—
0.61
273 vs 594
—
German
Mean age 97.9
—
—
Candidate Region/Gene
17493663
rs2590504
KIAA0649
—
0.00854
1173 vs 570
—
American
85-100
—
C
Genome-Wide Association Study
22533364
rs1048310
—
—
0.87
208 vs 399
—
Japanese
95+
—
—
Candidate Region/Gene
23770741
rs2024714
CDH4
—
7.43e-05
1173 vs 570
—
American
85-100
—
C
Genome-Wide Association Study
22533364
rs6519194
ATF4
—
0.41
206 vs 397
—
Japanese
95+
—
—
Candidate Region/Gene
23770741
rs1799752
ACE
—
0.025
394 vs 238
—
French
100.6 years
Insertion
—
Candidate Region/Gene
9761238
rs41383
NLRC5
—
0.00455
1173 vs 570
—
American
85-100
—
C
Genome-Wide Association Study
22533364
rs738288
ATF4
—
0.54
205 vs 396
—
Japanese
95+
—
—
Candidate Region/Gene
23770741
Arg 213 ->His
SULT1A1
—
0.017
Total 165
—
Nigerian
,
Caucasian
range 17- 90
SULT1A1*2
—
—
9854023
rs16975963
Noncoding
—
0.00713
1173 vs 570
—
American
85-100
—
G
Genome-Wide Association Study
22533364
rs6589722
—
—
0.015
209 vs 402
—
Japanese
95+
—
—
Candidate Region/Gene
23770741
APOE4
APOE
—
0.013
35 vs 125
—
Chinese
90 years or over
High E4 frequency
—
Candidate Region/Gene
11780357
epsilon2/3/4
APOE
—
0.05
67 vs 125
—
Italian
99+ (mean: 100±2)
epsilon4
—
Candidate Region/Gene
10643896
rs13008689
Intergenic
—
0.00686
1173 vs 570
—
American
85-100
—
A
Genome-Wide Association Study
22533364
rs12786104
CBL
—
0.12
210 vs 398
—
Japanese
95+
—
—
Candidate Region/Gene
23770741
-
TH
—
0.045
202 vs 170 vs 82
—
Italian
100-105 (oldest of 3 age groups, see notes)
—
—
Candidate Region/Gene
11053670
rs3120819
Intergenic
—
0.00806
1173 vs 570
—
American
85-100
—
C
Genome-Wide Association Study
22533364
rs11217184
CBL
—
0.8
212 vs 396
—
Japanese
95+
—
—
Candidate Region/Gene
23770741
rs2542052
APOC3
—
0.0001
Centenarians (n = 213) their offspring (n = 216) vs 258
—
Ashkenazi Jewish
Mean age 98.2
A
—
—
16602826
SV-6
CLU
—
1.0
49 vs 27 vs 20
—
Greek
,
Italian
99–107
—
—
Candidate Region/Gene
16804001
rs1061581
HSPA1B
—
0.05
191 vs 53
—
Chinese
>90
A
G
Candidate Region/Gene
19840767
I/D (insertion/deletion)
ACE
—
0.33
560 vs 560
—
French
centenarians 100th year or beyond, mean age 103.1
—
—
Candidate Region/Gene
11280044
rs9876781
Noncoding
—
0.000868
1173 vs 570
—
American
85-100
—
A
Genome-Wide Association Study
22533364
rs2249466
CBL
—
0.9
207 vs 394
—
Japanese
95+
—
—
Candidate Region/Gene
23770741
rs5882
CETP
—
0.069
Centenarians (n = 213) their offspring (n = 216) vs 258
—
Ashkenazi Jewish
Mean age 98.2
A
—
—
16602826
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25 of 1635 variants