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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs4986790 TLR4 0.61 273 vs 594 German Mean age 97.9 Candidate Region/Gene 17493663
rs2590504 KIAA0649 0.00854 1173 vs 570 American 85-100 C Genome-Wide Association Study 22533364
rs1048310 0.87 208 vs 399 Japanese 95+ Candidate Region/Gene 23770741
rs2024714 CDH4 7.43e-05 1173 vs 570 American 85-100 C Genome-Wide Association Study 22533364
rs6519194 ATF4 0.41 206 vs 397 Japanese 95+ Candidate Region/Gene 23770741
rs1799752 ACE 0.025 394 vs 238 French 100.6 years Insertion Candidate Region/Gene 9761238
rs41383 NLRC5 0.00455 1173 vs 570 American 85-100 C Genome-Wide Association Study 22533364
rs738288 ATF4 0.54 205 vs 396 Japanese 95+ Candidate Region/Gene 23770741
Arg 213 ->His SULT1A1 0.017 Total 165 Nigerian, Caucasian range 17- 90 SULT1A1*2 9854023
rs16975963 Noncoding 0.00713 1173 vs 570 American 85-100 G Genome-Wide Association Study 22533364
rs6589722 0.015 209 vs 402 Japanese 95+ Candidate Region/Gene 23770741
APOE4 APOE 0.013 35 vs 125 Chinese 90 years or over High E4 frequency Candidate Region/Gene 11780357
epsilon2/3/4 APOE 0.05 67 vs 125 Italian 99+ (mean: 100±2) epsilon4 Candidate Region/Gene 10643896
rs13008689 Intergenic 0.00686 1173 vs 570 American 85-100 A Genome-Wide Association Study 22533364
rs12786104 CBL 0.12 210 vs 398 Japanese 95+ Candidate Region/Gene 23770741
- TH 0.045 202 vs 170 vs 82 Italian 100-105 (oldest of 3 age groups, see notes) Candidate Region/Gene 11053670
rs3120819 Intergenic 0.00806 1173 vs 570 American 85-100 C Genome-Wide Association Study 22533364
rs11217184 CBL 0.8 212 vs 396 Japanese 95+ Candidate Region/Gene 23770741
rs2542052 APOC3 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 Ashkenazi Jewish Mean age 98.2 A 16602826
SV-6 CLU 1.0 49 vs 27 vs 20 Greek, Italian 99–107 Candidate Region/Gene 16804001
rs1061581 HSPA1B 0.05 191 vs 53 Chinese >90 A G Candidate Region/Gene 19840767
I/D (insertion/deletion) ACE 0.33 560 vs 560 French centenarians 100th year or beyond, mean age 103.1 Candidate Region/Gene 11280044
rs9876781 Noncoding 0.000868 1173 vs 570 American 85-100 A Genome-Wide Association Study 22533364
rs2249466 CBL 0.9 207 vs 394 Japanese 95+ Candidate Region/Gene 23770741
rs5882 CETP 0.069 Centenarians (n = 213) their offspring (n = 216) vs 258 Ashkenazi Jewish Mean age 98.2 A 16602826
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  • 25 of 1635 variants