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polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
mtDNA haplotype | — | — | 0.0052 | 212 vs 275 | — | Italian | 100+ | non-J haplogroups | — | Mitochondrial Haplogroup | 10463944 |
mt146 C>T | — | — | 0.005 | 113 (cases) vs 200 | — | Chinese | 90-110 | mt146T | mt146C | Complete Mitochondrial Genome | 22729909 |
rs1333049 | — | 0.64 | 0.001 | 80 (cases) vs 258 healthy young | — | Human | 100–104 | C | — | Candidate Region/Gene | 20230275 |
apoE haplotypes | — | — | 0.02 | 80 vs 391 | — | Greek | 80+ | Apo e4 | — | Candidate Region/Gene | 17234815 |
apoE haplotypes | — | — | 0.0042 | 3924 | — | American | 5-70 | Apo e4 | — | Candidate Region/Gene | 21332925 |
82133 G>A | — | — | 0.0189 | 33 vs 39 | — | Japanese | 90+ | A | — | Candidate Region/Gene | 15820493 |
G/A-IGF1R, Gly/Asp-IRS2, and Ala/Val-UCP2 allele combination | — | 3.19 | 0.0006 | 208 vs 514 | — | Italian | Mean age 96 | non-AAV allele combi | AAV allele combinati | Candidate Region/Gene | 21340542 |
IL6 VNTR A/B/C/D | — | 0.56 | 0.05 | 61 vs 94 | — | Italian | Mean age 100 | B | non-B | Candidate Region/Gene | 17506774 |
(HLA)-A1, B8, DR3 | — | — | 1.0 | 93 vs 100 | — | Irish | 80-97 years | — | — | Candidate Region/Gene | 12714268 |
rs16928120 | — | — | 0.00057 | 1600 samples (cases and controls combined) | — | German, Italian | — | — | — | Candidate Region/Gene | 19367319 |
rs4073591 | — | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
rs4930001 | — | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
rs16928120 | — | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
I carriers of ACE | — | — | 0.045 | 12 vs 190 vs 105 | — | Greek | 99-111 | — | — | Candidate Region/Gene | 23389097 |
XRCC3 intron 3 STR | — | — | 0.0005 | 430 (case) vs 290 | — | British | Mean age 70 | 15 | 13 | Candidate Region/Gene | 16518718 |
XRCC5 120 bp 5` (GAPyA)n STR | — | — | 0.0005 | 430 (case) vs 290 | — | British | Mean 70 | 16+2 | 15 | Candidate Region/Gene | 16518718 |
marker D4S1564 | — | — | 0.044 | 308 | — | European | min. age 98 for one sibling. 91+ males, 95+ females | — | — | Genome-Wide Association Study | 11526246 |
Haplogroup J | — | 0.38 | 0.025 | 98 vs 117 | — | Chinese | 90–100 | — | — | Candidate Region/Gene | 18759861 |
J mtDNA haplogroup | — | — | 0.027 | 138 vs 138 | — | Spaniard | >85 (oldest age group) | — | — | — | 18931934 |
3p24.2–22.3 | — | — | 0.037 | 632 (total) | — | Caucasian | By Expected age of death: Male 90-100, Female 95-104 | — | — | Genome-Wide Association Study | 20824210 |
9q31.3–34.2 | — | — | 0.054 | 632 (total) | — | Caucasian | By Expected age of death: Male 90-100, Female 95-104 | — | — | Genome-Wide Association Study | 20824210 |
mtDNA C150T | — | — | 0.936 | 556 vs 403 | — | Chinese | 90–108 (94.59±3.34) | — | — | Candidate Region/Gene | 21262335 |
rs3811952, rs155979, rs3762985 | — | 0.54 | 0.008 | 137 vs 213 | — | Korean | Mean age 90 | CGA | — | Genome-Wide Association Study | 19641380 |
rs712700 | — | 1.87 | 0.01 | 137 vs 213 | — | Korean | Mean age 90 | — | G | Genome-Wide Association Study | 19641380 |
rs327512 | — | 5.55 | 0.005 | 137 vs 213 | — | Korean | Mean age 90 | — | G | Genome-Wide Association Study | 19641380 |