Symbol: GHR Name: growth hormone receptor Entrez gene ID: 2690 Ensembl gene ID: ENSG00000112964 Species: Human (Taxid: 9606) Function: Growth hormone binding protein Observation: Individuals with low GH/IGF-I signaling due to a defect in the growth hormone receptor (GHR) are protected against cancer. Among the human individuals with a defect in GHR no cancer deaths were observed. GHR deficiency does not appear to extend lifespan because it is associated with increased risk of heart disease [21325617]. Variants in GHR were found to be associated with longevity [19489743]. Assays: Organismal Lifespan Longevity Associated Variants: Classification: Type: References: Aging Relevance Analysis/Source: Homologs Orthologs Inparanoids Edit \ Update (Admin) | Delete |
Comment on This Data Unit