Polymorphism: rs4880
rs4880
(
SNPedia |
23andMe
)
Location: 6q25.3
Factor:
- Symbol: SOD2
- Name: superoxide dismutase 2, mitochondrial
- Entrez ID: 6648
- Ensembl ID: ENSG00000112096
Factors:
SOD2
superoxide dismutase 2, mitochondrial
(
6648
/
ENSG00000112096
)
Description:
the effect of the advantageous genotype on mortality was most pronounced for males_x000D_. The same individuals were used 10 years later, those surviving were to be the cases, while the original cohort was used as the control group -- 61 survived.x000D
Ethnicity:
Danish
Age of cases: All danes born in 1905 (Danish 1905 cohort)
Shorter lived allele: T
Statistics
- Number of cases/controls: 1650 (initial)
- Odds ratio: 0.91
- p-value:
0.002
[0.002]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: ABI Prism 7700 Sequence Detector (Applied Biosystems)
Reference:
19428448: The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old.
Choice: Curate
Created: July 2, 2013, 2:47 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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