Polymorphism: APOE4


Location: 19q13.31

Factor:
- Symbol: APOE
- Name: apolipoprotein E
- Entrez ID: 348
- Ensembl ID: ENSG00000130203

Factors:
  • APOE apolipoprotein E ( 348 / ENSG00000130203 )


  • Description:

    Aim: connection of effectiveness of beta-carotene treatment of Alzheimer disease with the presence or absence of APOE4 allele and some other factors of life.

    Note: longer-lived allele

    Ethnicity: American
    Age of cases: 70-79 (duration of study - 7 years)
    Shorter lived allele: e4

    Statistics
    - Number of cases/controls: 106 vs 349 (initial)
    - p-value: 0.71
    - Significant: No

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR

    Reference:
    16799145: Association between serum beta-carotene levels and decline of cognitive function in high-functioning older persons with or without apolipoprotein E 4 alleles: MacArthur studies of successful aging.

    Choice: Discard
    Created: June 30, 2013, midnight
    Updated: Aug. 8, 2014, 1:05 p.m.

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