Polymorphism: APOA1-MspI-RFLP (−75)
Location: 11q23-q24
Factor:
- Symbol: APOA1
- Name: apolipoprotein A-I
- Entrez ID: 335
- Ensembl ID: ENSG00000118137
Factors:
APOA1
apolipoprotein A-I
(
335
/
ENSG00000118137
)
Description:
Allele defined as Absence/Presence of the restriction site. Signf. in males
Ethnicity:
Calabrian
Age of cases: 81–109 (median 101)
Shorter lived allele: A (=Absence)
Statistics
- Number of cases/controls: 229 vs 571 (initial)
- p-value:
0.016
[0.016]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: MspI Restriction analysis after PCR- amplification of the DNA regions containing the restriction sites
Reference:
12556235: The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects.
Choice: Curate
Created: July 2, 2013, 2:47 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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