Denigma Buck Institute Health Extension
Polymorphism: rs1800795
rs1800795 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 7p21

Factor:
- Symbol: IL-6
- Name: interleukin 6 (interferon, beta 2)
- Entrez ID: 3569
- Ensembl ID: ENSG00000136244

Factors:
  • IL-6 interleukin 6 (interferon, beta 2) ( 3569 / ENSG00000136244 )


    • Description:

    locus GG homozygous men, are disadvantaged for longevity. Significant only for male.

    Trivial name is –174 C/G

    Ethnicity: Italian
    Age of cases: median age = 101
    Shorter lived allele: G
    Longer lived allele: C
    Finding: Positive

    Statistics
    - Number of cases/controls: 323 (cases) vs 377 (initial) (initial)
    - p-value: 0.007 [0.007]
    - Significant: yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR

    Reference:
    11500818: A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity.

    Choice: Clean
    Created: July 2, 2013, 2:47 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

    Edit (Admin) | Delete