Polymorphism: epsilon2/3/4
Location: 19q13.2
Factor:
- Symbol: APOE
- Name: apolipoprotein E
- Entrez ID: 348
- Ensembl ID: ENSG00000130203
Factors:
APOE
apolipoprotein E
(
348
/
ENSG00000130203
)
Description:
The paper references several studies regarding the association of ApoE genotypes to longevity (as well as AD). Seems like a meta-analysis mostly._x000D_The results (p-value/signf.) shown here refer to the data aquired in this study combined with previous studies of french and finnish populations. Maybe this study should be disregarded.
Ethnicity:
Italian
Age of cases: 99+ (mean: 100±2)
Shorter lived allele: epsilon4
Finding: Positive
Statistics
- Number of cases/controls: 67 vs 125 (initial)
- p-value:
0.05
[<0.05]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: CfoI Restriction site to PCR products, on 8% polyacrylamide gel with silver staining method
Reference:
10643896: Decreased frequency of apolipoprotein E epsilon4 allele from Northern to Southern Europe in Alzheimer's disease patients and centenarians.
Choice: Curate
Created: July 2, 2013, 2:47 a.m.
Updated: Aug. 8, 2014, 1:05 p.m.
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