Polymorphism: HLA-C phenotype
Variant Type: Locus
Location: 6p21.3
Factor:
- Symbol: HLA-C
- Name: major histocompatibility complex, class I, C
- Entrez ID: 3107
- Ensembl ID: ENSG00000204525
Factors:
HLA-C
major histocompatibility complex, class I, C
(
3107
/
ENSG00000204525
)
Description:
Cw3 has lower frequency in centenarian (p=0.02, OR=0.49)
Cw6 has lower frequency in centenarian (p=0.04, OR=0.35)
Cw7 has lower frequency in centenarian (p=0.02, OR=0.39).
Ethnicity:
Chinese
Age of cases: >93
Shorter lived allele: Cw3, Cw6. Cw7
Finding: Positive
Statistics
- Number of cases/controls: 201 vs 211 (initial)
- Odds ratio: 0.49
- Odds ratio type: Longer
- p-value:
0.02
[0.02]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: Serological tests
Reference:
9147371: HLA and longevity or aging among Shanghai Chinese.
Choice: Clean
Created: July 2, 2013, 2:47 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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