Polymorphism: HLA-A phenotype



Variant Type: Locus
Location: 6p21.3

Factor:
- Symbol: HLA-A
- Name: major histocompatibility complex, class I, A
- Entrez ID: 3105
- Ensembl ID: ENSG00000206503

Factors:
  • HLA-A major histocompatibility complex, class I, A ( 3105 / ENSG00000206503 )


  • Description:

    For males A9 allele has higher frequency with p=0.0002 and OR 3.27, for total aged population A9 has higher frequency with p=0.002 and OR=1.97. A30 allele is less frequent in aged group (p=0.008, OR=0.43)

    Ethnicity: Chinese
    Age of cases: 22 centenarians + 179 nonagenarians (mean age 93 ±1.04)
    Shorter lived allele: A9
    Longer lived allele: A30
    Finding: Positive

    Statistics
    - Number of cases/controls: 201 vs 211 (initial)
    - Odds ratio: 1.95
    - Odds ratio type: Longer
    - p-value: 0.002 [0.002]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: Serological tests

    Reference:
    9147371: HLA and longevity or aging among Shanghai Chinese.

    Choice: Clean
    Created: July 2, 2013, 2:47 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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