Polymorphism: HLA-A phenotype
Variant Type: Locus
Location: 6p21.3
Factor:
- Symbol: HLA-A
- Name: major histocompatibility complex, class I, A
- Entrez ID: 3105
- Ensembl ID: ENSG00000206503
Factors:
HLA-A
major histocompatibility complex, class I, A
(
3105
/
ENSG00000206503
)
Description:
For males A9 allele has higher frequency with p=0.0002 and OR 3.27, for total aged population A9 has higher frequency with p=0.002 and OR=1.97.
A30 allele is less frequent in aged group (p=0.008, OR=0.43)
Ethnicity:
Chinese
Age of cases: 22 centenarians + 179 nonagenarians (mean age 93 ±1.04)
Shorter lived allele: A9
Longer lived allele: A30
Finding: Positive
Statistics
- Number of cases/controls: 201 vs 211 (initial)
- Odds ratio: 1.95
- Odds ratio type: Longer
- p-value:
0.002
[0.002]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: Serological tests
Reference:
9147371: HLA and longevity or aging among Shanghai Chinese.
Choice: Clean
Created: July 2, 2013, 2:47 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.
Edit
(
Admin) |
Delete